Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii
| Autor: | Lei-Yu Ke, Yu Zhang, Chunlin Long, Yue-Hu Wang, Meng-Yuan Xia, Jing-Xian Zhuo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Selaginellaceae
Stereochemistry Pharmaceutical Science HL-60 Cells 010402 general chemistry 01 natural sciences Analytical Chemistry chemistry.chemical_compound Selaginella moellendorffii Cell Line Tumor Drug Discovery Humans Moiety Abietane Pharmacology biology 010405 organic chemistry Organic Chemistry biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid 0104 chemical sciences Complementary and alternative medicine chemistry A549 Cells Abietanes MCF-7 Cells Molecular Medicine Diterpenes Diterpene Human cancer |
| Zdroj: | Journal of Natural Products. 81:418-422 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.7b00909 |
| Popis: | A new modified abietane diterpenoid, (3S,4S,5R,10S)-18(4→3)-abeo-3,4,12,18-tetrahydroxy-8,11,13-abietatrien-7-one (1), and two novel dimers, selaginedorffones A (2) and B (3), featuring a new cyclohexene moiety that was biogenetically constructed from two modified abietane diterpenoids through a Diels–Alder reaction were obtained from a methanolic extract of Selaginella moellendorffii, a traditional Chinese herb. The structures of 1–3 were identified by a combination of NMR spectroscopic analysis and ECD calculations. In the present study, diterpenoids were identified from S. moellendorffii for the first time, which supports the presence of diterpene synthases in this plant. These three diterpenoids (1–3) were evaluated for their growth-inhibitory activities against several human cancer cell lines. Of these substances, selaginedorffone B (3) showed cytotoxicity against the MCF-7 human-breast-cancer-cell line (IC50 9.0 μM). |
| Databáze: | OpenAIRE |
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