Maxwell's equations explain why irreversible electroporation will not heat up a metal stent
| Autor: | Cees W. M. van der Geld, Marc G. Besselink, Rudolf M. Verdaasdonk, Martijn R. Meijerink, Willemien van den Bos, Jantien A. Vogel, Ruben T. van Gaalen, Martin J. C. van Gemert, Hester J. Scheffer |
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| Přispěvatelé: | Radiology and nuclear medicine, CCA - Cancer Treatment and quality of life, Process and Product Design, Mechanical Engineering, Power & Flow, Health Technology Implementation, TechMed Centre, Urology, Gastroenterology and Hepatology, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, Surgery, Biomedical Engineering and Physics, APH - Personalized Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
medicine.medical_treatment UT-Hybrid-D 02 engineering and technology SDG 3 – Goede gezondheid en welzijn 01 natural sciences 010305 fluids & plasmas symbols.namesake SDG 3 - Good Health and Well-being Electric field Irreversible electroporation 0103 physical sciences medicine Stent Heat conduction Fluid Flow and Transfer Processes Mechanical Engineering Tissue Model Mechanics 021001 nanoscience & nanotechnology Condensed Matter Physics Thermal conduction equipment and supplies Maxwell's equations Heat generation symbols Ablation Therapy 0210 nano-technology |
| Zdroj: | International Journal of Heat and Mass Transfer, 169:120962. Elsevier Ltd International Journal of Heat and Mass Transfer, 169:120962. Elsevier International journal of heat and mass transfer, 169:120962. Elsevier International journal of heat and mass transfer, 169:120962. Elsevier Limited van der Geld, C W M, van Gaalen, R T, Scheffer, H J, Vogel, J A, van den Bos, W, Meijerink, M R, Besselink, M G H, Verdaasdonk, R M & van Gemert, M J C 2021, ' Maxwell's equations explain why irreversible electroporation will not heat up a metal stent ', International Journal of Heat and Mass Transfer, vol. 169, 120962 . https://doi.org/10.1016/j.ijheatmasstransfer.2021.120962 |
| ISSN: | 0017-9310 |
| Popis: | Irreversible Electroporation (IRE) is a promising clinical ablation therapy for the treatment of cancer, but issues with the generation of heat must be solved before safe and effective clinical results can be obtained. In the present study, we show that a metal stent will not be noticeably heated up by IRE pulses under typical clinical conditions. Derivation of this non-intuitive result required the application of Maxwell's equations to the tissue-stent configuration. Subsequently, straightforward and arguably accurate simplifications of the electric field generated by two needles in tissue surrounding a metal stent have enabled the modeling of the heat generation and the transport of heat in IRE procedures. Close to a stent that is positioned in between two needles, temperatures in a typical run of 100 s, 1 Hz pulses, may remain notably lower than without the stent. This is the explanation of the experimentally observed low temperature rim of viable tissue around the stent, whereas all tissue was non-viable without stent, found in tissue model experiments. |
| Databáze: | OpenAIRE |
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