Circadian rhythm of ornithine decarboxylase activity in small intestine of fasted rats
| Autor: | Johnson Lr, Price Vh, Fujimoto K, Toshiie Sakata, Patrick Tso, D N Granger |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Duodenum Period (gene) Ileum Biology Ornithine Decarboxylase General Biochemistry Genetics and Molecular Biology Ornithine decarboxylase Jejunum Internal medicine Intestine Small medicine Animals Circadian rhythm Intestinal Mucosa chemistry.chemical_classification fungi Rats Inbred Strains Fasting Small intestine Circadian Rhythm Rats medicine.anatomical_structure Enzyme Endocrinology chemistry Food |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 200(3) |
| ISSN: | 0037-9727 |
| Popis: | The aim of this study was to determine whether the circadian changes in ornithine decarboxylase (ODC) activity of different segments of the small intestine were governed by factors other than food intake. First, the effects of fasting on mucosal ODC activity were examined. The results indicate that mucosal ODC activity in 24 hr and 48 hr fasted rats decreased significantly compared with ad libitum-fed rats. Second, the circadian rhythm of mucosal ODC activity was characterized by measuring mucosal ODC activity in fasted rats at four time points (09:00, 15:00, 21:00, and 03:00 hr; light period: 06:00-18:00 hr). The results from this study indicate that there is a detectable baseline ODC activity in different segments of fasting intestine. In duodenum, mucosal ODC activity was highest at 15:00 hr (light period), a time at which the rat was normally not eating. In jejunum and ileum, mucosal ODC activity increased between 21:00 and 03:00 hr (dark period). The observation that small intestine exhibits a distinct circadian rhythm of ODC activity in fasted rats suggests that not only food but also intrinsic factors can modulate physiologic oscillations in mucosal ODC activity. |
| Databáze: | OpenAIRE |
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