Liver involvement is associated with blood culture positivity and high agglutination titre in patients with brucellosis in Turkey
| Autor: | Gurhan Sisman, Huseyin Sahinturk, Reskan Altun, Bulent Baran |
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| Přispěvatelé: | Baran, Bülent (ORCID 0000-0001-7966-2346 & YÖK ID 167583), Şahintürk, Hüseyin, Şişman, Gürhan, Altun, Reskan, Koç University Hospital |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Turkey 030106 microbiology Injections Intramuscular Gastroenterology Microbiology Brucellosis 03 medical and health sciences Liver Function Tests Internal medicine medicine Humans Hepatitis Blood culture Brucella agglutination titre Transaminases Aspartate Aminotransferases Prospective Studies Doxycycline biology medicine.diagnostic_test business.industry Incidence Liver Diseases Alanine Transaminase Hemagglutination Tests General Medicine Middle Aged medicine.disease Anti-Bacterial Agents Blood Alanine transaminase Blood Culture Streptomycin biology.protein Elevated transaminases Female business Liver function tests medicine.drug |
| Zdroj: | Journal of Medical Microbiology |
| Popis: | We investigated the incidence of and risk factors for liver involvement (LI) in patients with brucellosis in Turkey. Diagnosis was established by blood cultures (BCs) or compatible clinical presentation accompanied by serological evidence. Patients received either a combination of doxycycline plus rifampin for 6 weeks or doxycycline for 6 weeks plus streptomycin intramuscularly for the first 2 weeks. Liver function tests, including those for alanine (ALT) and aspartate aminotransferase (AST) levels, were monitored before and at the end of treatment. One hundred and ninety-five patients were included in the study. Seventy patients had elevated transaminases before treatment. Twenty-six patients had a positive BC for brucellosis. In multivariate analysis, BC positivity (OR=2.44, 95% CI: 1.03-5.78, P=0.043) and serum agglutination titre (SAT) (OR=1.001, 95% CI: 1.00-1.002, P=0.018) were found to be associated with LI. Serum aminotransferase levels were normalized in all patients with bruc NA |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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