Alien domains shaped the modular structure of plant NLR proteins
| Autor: | Maria Raffaella Ercolano, Pasquale Chiaiese, Antonino De Natale, Giuseppe Andolfo, Antonino Pollio, Luigi Frusciante, Antimo Di Donato, Jonathan D. G. Jones |
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| Přispěvatelé: | Andolfo, Giuseppe, Donato, Antimo Di, Chiaiese, Pasquale, Natale, Antonino De, Pollio, Antonino, Jones, Jonathan D G, Frusciante, Luigi, Ercolano, Maria |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Gene Transfer Horizontal NLR Proteins chemical and pharmacologic phenomena Viridiplantae 010603 evolutionary biology 01 natural sciences Genome Evolution Molecular 03 medical and health sciences Protein Domains Phylogenetics Chlorophyta Operon Genetics Plant Immunity Nucleotide Motifs R gene supra domain Ecology Evolution Behavior and Systematics Phylogeny 030304 developmental biology Disease Resistance Plant Proteins 0303 health sciences Innate immune system biology phylogenetic analysis fungi Genomics Plants biology.organism_classification Transmembrane protein NLR gene family Horizontal gene transfer horizontal gene transfer Genome Plant Research Article |
| Zdroj: | Genome Biology and Evolution |
| Popis: | Plant innate immunity mostly relies on nucleotide-binding (NB) and leucine-rich repeat (LRR) intracellular receptors to detect pathogen-derived molecules and to induce defense responses. A multi-taxa reconstruction of NB-domain associations allowed us to identify the first NB-LRR arrangement in the Chlorophyta division of the Viridiplantae. Our analysis points out that the basic NOD-like receptor (NLR) unit emerged in Chlorophytes by horizontal transfer and its diversification started from TIR-NB-LRR (TNL) members. The operon-based genomic structure of Chromochloris zofingiensis NLR copies suggests a functional origin of NLR clusters. Moreover, the transmembrane signatures of NLR proteins in the unicellular alga C. zofingiensis supports the hypothesis that the NLR-based immunity system of plants derives from a cell-surface surveillance system. Taken together, our findings suggest that NLRs originated in unicellular algae and may have a common origin with cell surface LRR receptors. |
| Databáze: | OpenAIRE |
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