Isoprostane as a marker of oxidative stress in chronic heroin users: correlation with duration of heroin use or concomitant hepatitis C infection

Autor:	Kakia Nikolaou, Alexandra Tsolakidou, Leda Kovatsi, Samuel Njau, Katerina Thisiadou, Ioannis Karamouzis
Rok vydání:	2010
Předmět:	Adult Male Pathology medicine.medical_specialty Isoprostane Time Factors Medicine (miscellaneous) Physiology medicine.disease_cause Heroin chemistry.chemical_compound mental disorders Blood plasma Medicine Humans F2-Isoprostanes business.industry Heroin Dependence Case-control study Hepatitis C Hepatitis C Antibodies medicine.disease Psychiatry and Mental health Clinical Psychology Oxidative Stress chemistry Concomitant Case-Control Studies Chronic Disease business Viral hepatitis Oxidative stress Biomarkers medicine.drug
Zdroj:	The American journal of drug and alcohol abuse. 36(1)
ISSN:	1097-9891
Popis:	Although chronic heroin abuse has been extensively linked to oxidative stress, and while plasma 15-F(2t)-IsoP is considered a good indicator of oxidative stress, there remain few references in the literature about the plasma concentration of this marker in heroin dependent subjects.To determine plasma 15-F(2t)-IsoP, as a marker of oxidative stress, in chronic heroin users, and to examine whether the values of this marker correlate with the duration of heroin use or with the presence of anti-HCV antibodies.Forty-two chronic heroin users and twenty two healthy control subjects were recruited for this study. An enzyme-immunoassay method was used for the determination of 15-F(2t)-IsoP in plasma.Plasma 15-F(2t)-IsoP values were significantly higher in chronic heroin users compared to healthy controls. No correlation was found between the values of plasma 15-F(2t)-IsoP and the duration of heroin use. Heroin dependent subjects positive for anti-HCV antibodies had significantly lower values of plasma 15-F(2t)-IsoP as compared to those without a history of HCV infection.The elevated plasma 15-F(2t)-IsoP values in heroin dependent subjects, compared to healthy individuals, indicate a shift of the balance between oxidants and antioxidants towards the former and suggest that heroin dependent subjects could benefit from an antioxidant therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2b22c5a6352cb6605a9390ccc84a75 https://pubmed.ncbi.nlm.nih.gov/20141391 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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