Contribution of Crk Adaptor Proteins to Host Cell and Bacteria Interactions
| Autor: | Narcisa Martinez-Quiles, Philip R. Hardwidge, María Benito-León, Leigh Ann Feuerbacher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
animal structures
lcsh:Medicine Review Article Yersinia General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Adapter molecule crk Enteropathogenic Escherichia coli Structure-Activity Relationship Cell Adhesion Humans Protein Isoforms Phosphorylation Cell adhesion 030304 developmental biology Genetics 0303 health sciences General Immunology and Microbiology biology lcsh:R 030302 biochemistry & molecular biology Alternative splicing Signal transducing adaptor protein General Medicine Proto-Oncogene Proteins c-crk biology.organism_classification 3. Good health Cell biology CRKL Alternative Splicing Gene Expression Regulation embryonic structures Host-Pathogen Interactions Signal transduction Signal Transduction |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | The Crk adaptor family of proteins comprises the alternatively spliced CrkI and CrkII isoforms, as well as the paralog Crk-like (CrkL) protein, which is encoded by a different gene. Initially thought to be involved in signaling during apoptosis and cell adhesion, this ubiquitously expressed family of proteins is now known to play essential roles in integrating signals from a wide range of stimuli. In this review, we describe the structure and function of the different Crk proteins. We then focus on the emerging roles of Crk adaptors during Enterobacteriaceae pathogenesis, with special emphasis on the important human pathogensSalmonella,Shigella,Yersinia, and enteropathogenicEscherichia coli. Throughout, we remark on opportunities for future research into this intriguing family of proteins. |
| Databáze: | OpenAIRE |
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