C-Reactive protein and SOFA score as early predictors of critical care requirement in patients with COVID-19 pneumonia in Spain

Autor: Luis Mario Vaquero-Roncero, Elisa Sánchez-Barrado, Daniel Escobar-Macias, Pilar Arribas-Pérez, Jose Ramón Gonzalez-Porras, Jesús F Bermejo-Martín, Cristina Doncel, JM Bastida, Azucena Hernández-Valero, Carolina Jambrina-García Montoto, José Sánchez-Crespo, Pablo Alonso-Hernández, Domingo Bustos-García, Antonio Rodríguez-Calvo, Gerardo Riesco-Galache, Raúl Alzibeíro, Alberto Hernández-Sánchez, Rocío Eiros, M Carmen Vargas, María Ángeles Martín, Teresa López, José Alfonso Sastre, José Carlos Garzón, Mar Fernández, Belén García, M Magdalena Muñoz, María Isabel Martínez, Gonzalo García, Agustín Díaz, Edgar Marcano, Víctor Sagredo-Meneses, Miguel Vicente Sánchez-Hernandez
Rok vydání: 2020
Předmět:
DOI: 10.1101/2020.05.22.20110429
Popis: BackgroundSome patients infected by SARS-CoV-2 in the recent pandemic have required critical care, becoming one of the main limitations of the health systems. Our objective has been to identify potential markers at admission predicting the need for critical care in patients with COVID-19 pneumonia.MethodsWe retrospectively collected and analyzed data from electronic medical records of patients with laboratory-confirmed SARS-CoV-19 infection by real-time RT-PCR. A comparison was made between patients staying in the hospitalization ward with those who required critical care. Univariable and multivariable logistic regression methods were used to identify risk factors predicting critical care need.FindingsBetween March 15 and April 15, 2020, 150 patients under the age of 75 were selected (all with laboratory confirmed SARS-CoV-19 infection), 75 patients requiring intensive care assistance and 75 remaining the regular hospitalization ward. Most patients requiring critical care were males, 76% compared with 60% in the non-critical care group (pInterpretationPatients COVID-19 positive presenting at admission with high SOFA score ≥2 combined with CRP ≥ 9,1 mg/mL could help clinicians to identify them as a group that will more likely require critical care so further actions might be implemented to improve their prognosis.
Databáze: OpenAIRE