Research progress in galactomannan-based nanomaterials: Synthesis and application
| Autor: | Harsh Yadav, Sabyasachi Maiti |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biocompatible Materials
Nanotechnology 02 engineering and technology Polysaccharide Galactans Biochemistry Mannans 03 medical and health sciences Galactomannan chemistry.chemical_compound Drug Delivery Systems Polysaccharides Structural Biology Plant Gums Humans skin and connective tissue diseases Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Guar gum Chemistry Galactose General Medicine 021001 nanoscience & nanotechnology Nanostructures Trigonella Drug delivery Self-healing hydrogels Cassia gum Locust bean gum Nanocarriers 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 163:2113-2126 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2020.09.062 |
| Popis: | Galactomannans are naturally occurring biocompatible and biodegradable nonionic polysaccharides comprised of mannose and galactose residues. They are under investigation for the design of various drug delivery carriers such as matrix tablets, microparticles, nanoparticles/nanocomposites, polymeric micelles, hydrogels, as well as pharmaceutical excipients. Amongst galactomannans, guar gum, locust bean gum, and fenugreek gum are the biomaterials mostly investigated for their potential utility as nanocarriers for various purposes, either in their native or modified forms. The galactomannan-based nanomaterials have been fabricated by adopting various strategies. These galactomannan nanomaterials have been tested for oral vaccination, oral insulin delivery, cancer cell & macrophage targeting, controlled drug delivery, heavy metal extraction and wound dressing applications. The galactomannan has attracted the attention of researchers as reducing agents for the green synthesis of metal nanoparticles as well. These nanometals have shown improved antimicrobial, antioxidant and anticancer activities. In vitro toxicity of the nanomaterials is also assessed in some instances. Others such as cassia gum, tara gum, Delonix, Leucaena leucocephala, Punica granatum galactomannans are amongst the least studied materials for biological applications. This review describes various strategies adopted for the synthesis of galactomannan-based nanomaterials, their properties and applications, especially in the field of drug delivery. |
| Databáze: | OpenAIRE |
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