Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

Autor: Olivier Berdeaux, Elodie Masson, Stéphane Grégoire, Roman Walle, Véronique De Smedt-Peyrusse, Lucy Martine, Frank Aby, Clémentine Bosch-Bouju, Baptiste Caraballo, Suzanne van der Veldt, David W.L. Ma, Xavier Fioramonti, Jean-Christophe Helbling, Jing X. Kang, Sophie Layé, Gabriel Barreda-Gómez, Pierre Trifilieff, Sylvie Vancassel, Stéphanie Cabaret, Guillaume Ferreira, Marie-Lou Boyer, Tarson Tolentino-Cortez, Fabien Ducrocq, Asma Oummadi, Andrea Contini
Přispěvatelé: Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), IMG Pharma Biotech S.L., Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Massachusetts General Hospital, Harvard Medical School [Boston] (HMS), University of Guelph, Nutrition et Neurobiologie intégrée (NutriNeur0), Ecole nationale supérieure de chimie, biologie et physique-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, Partenaires INRAE, Université de Bourgogne (UB), Massachusetts General Hospital [Boston], Department of Human Health and Nutritional Sciences
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
N-3 PUFA
Physiology
[SDV]Life Sciences [q-bio]
Dopamine
Mice
Transgenic

Nucleus accumbens
Medium spiny neuron
Mice
03 medical and health sciences
0302 clinical medicine
Dopamine receptor D2
Fatty Acids
Omega-3

medicine
Animals
Molecular Biology
Pathological
030304 developmental biology
Neurons
Medium spiny neurons
chemistry.chemical_classification
[SDV.GEN]Life Sciences [q-bio]/Genetics
0303 health sciences
Motivation
Receptors
Dopamine D2

business.industry
[SCCO.NEUR]Cognitive science/Neuroscience
Cell Biology
Mice
Inbred C57BL

Electrophysiology
[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
030104 developmental biology
chemistry
Female
Polyunsaturated fatty acids
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Causal link
business
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Polyunsaturated fatty acid
Zdroj: Cell Metabolism
Cell Metabolism, Elsevier, 2019, 31 (4), pp.755-772.e7. ⟨10.2139/ssrn.3382436⟩
Cell Metabolism, Elsevier, 2020, 31 (4), pp.755-772. ⟨10.1016/j.cmet.2020.02.012⟩
Cell Metabolism, Elsevier, 2019, online first, ⟨10.2139/ssrn.3382436⟩
ISSN: 1550-4131
Popis: International audience; Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational impairments. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) onto dopamine D1 receptor-expressing MSNs in the nucleus accumbens, a main brain region for the modulation of motivation. Strikingly, transgenically preventing n-3 PUFA deficiency selectively in D2-expressing neurons normalizes MSN collateral inhibition and enhances motivation. These results constitute the first demonstration of a causal link between a behavioral deficit and n-3 PUFA decrease in a discrete neuronal population and suggest that lower n-3 PUFA biostatus in psychopathologies could participate in the etiology of reward-related symptoms.
Databáze: OpenAIRE