Extensively drug-resistant Pseudomonas aeruginosa: risk of bloodstream infection in hospitalized patients
| Autor: | Carmen Peña, Fe Tubau, Olga Arch, Miquel Pujol, Cristina Suárez, Antonio Oliver, Silvia Gómez-Zorrilla, Javier Ariza, María Ángeles Domínguez |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Population Bacteremia Drug resistance Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Genetic Heterogeneity Medical microbiology Risk Factors Drug Resistance Multiple Bacterial medicine Pulsed-field gel electrophoresis Confidence Intervals Odds Ratio Humans Pseudomonas Infections education Aged Retrospective Studies Aged 80 and over education.field_of_study Pseudomonas aeruginosa Retrospective cohort study General Medicine Odds ratio Middle Aged medicine.disease Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Hospitalization Infectious Diseases Logistic Models Phenotype Spain Female Fluoroquinolones |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 31(10) |
| ISSN: | 1435-4373 |
| Popis: | Several studies have suggested that resistance determinants usually reduce virulence. However, their contribution to decrease bloodstream infections is unclear. Our aim was to identify risk factors of extensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) bacteremia and to assess the prevalence of XDR-PA bacteremia. A retrospective study of PA bloodstream infections in our patient population with at least one clinical sample isolate due to PA (2006–2007) was carried out. A total of 2,131 patients with PA clinical samples were detected. Among 1,657 patients with susceptible-PA isolates, 95 developed PA-susceptible bacteremia. Concomitantly, among 474 patients with multidrug-resistant (MDR)-PA isolates, 265 with XDR-PA, and 209 with non-XDR MDR-PA, 43 developed XDR-PA bacteremia and 13 non-XDR MDR-PA bacteremia, respectively. Pulsed-field gel electrophoresis (PFGE) revealed the clonal nature of the two predominant XDR-PA phenotypes and genetic heterogeneity in non-XDR MDR-PA phenotypes. The proportion of XDR-PA bacteremia was higher than the proportion of bacteremia in the susceptible-PA population (16 % vs. 6 %; p |
| Databáze: | OpenAIRE |
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