Cruciferous Vegetables, Mushrooms, and Gastrointestinal Cancer Risks in a Multicenter, Hospital-Based Case-Control Study in Japan
Autor: | Helena Yukari Adachi, Minatsu Kobayashi, Tomoyuki Hanaoka, Yoichi Koizumi, Tetsuya Otani, Shoichiro Tsugane, Tsunetomo Matsuzawa, Megumi Hara, Syusuke Natsukawa, Kozo Shaura, Ai Montani, Yoshio Kasuga, Satoshi Sasaki, Tetsuro Ikekawa |
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Rok vydání: | 2003 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Colorectal cancer Medicine (miscellaneous) Brassica Gastroenterology Japan Risk Factors Stomach Neoplasms Internal medicine Vegetables Epidemiology Humans Medicine Gastrointestinal cancer Risk factor Stomach cancer Aged Gastrointestinal Neoplasms Nutrition and Dietetics business.industry Cruciferous vegetables Case-control study Odds ratio Middle Aged medicine.disease Carotenoids Hospitals Diet Surgery Oncology Case-Control Studies Brassicaceae Female Agaricales Colorectal Neoplasms business |
Zdroj: | Scopus-Elsevier |
ISSN: | 1532-7914 0163-5581 |
DOI: | 10.1207/s15327914nc4602_06 |
Popis: | We assessed the possible association of gastrointestinal cancers with cruciferous vegetables and mushrooms in a multicenter, hospital-based case-control study in an agricultural area of Japan. One hundred forty-nine cases and 287 controls for stomach cancer and 115 cases and 230 controls for colorectal cancer were matched by age, sex, and residential area. In stomach cancer, the protective effect of vegetables (consumption of total vegetable) was obscure, but it became clearer when we examined specific kinds of vegetables. Marginal associations were observed in the group of the highest consumption of Chinese cabbage (odds ratio [OR] = 0.61; 95% confidence interval [CI] = 0.35-1.07), broccoli (OR = 0.60; 95% CI = 0.34-1.08), Hypsizigus marmoreus (Bunashimeji) (OR = 0.57; 95% CI = 0.31-1.04) and Pholita nameko (Nameko) (OR = 0.56; 95% CI = 0.30-1.06). In colorectal cancer, we observed decreased risks from the highest tertile of total vegetables (OR = 0.22; 95% CI = 0.08-0.66) and low-carotene-containing vegetables (OR = 0.28; 95% CI = 0.08-0.77), and inverse associations were observed in the group of the highest consumption of broccoli (OR = 0.18; 95% CI = 0.06-0.58). Although the sample size was limited, subgroup analyses showed that the associations differed with the histopathological subtype. These findings suggest that cruciferous vegetables decrease the risk of both stomach and colorectal cancer, and that mushrooms are associated with a decreased risk of stomach cancer. |
Databáze: | OpenAIRE |
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