Genome-wide association study of Tourette's syndrome
Autor: | Lea K. Davis, Harvey S. Singer, Thomas L. Lowe, Jacquelyn Crane, James F. Leckman, P. C. Lee, Simon Girard, Yves Dion, Danielle Posthuma, Rainald Moessner, Gary A. Heiman, Jubel Morgan, Gholson J. Lyon, K. Anderson, Andres Ruiz-Linares, William Cornejo Ochoa, Robert A. King, Daniel B. Mirel, Jesen Fagerness, Gerald Erenberg, John T. Walkup, Patrick Evans, Pieter J. Hoekstra, Buhm Han, James A. Knowles, Desmond Campbell, Paul Sandor, Gabriel Bedoya Berrío, Martha Rangel-Lugo, Eric R. Gamazon, Lisa Osiecki, William M. McMahon, Eric Strengman, S. E. Stewart, Mark Leppert, David L. Pauls, Anna Pluzhnikov, Luis Diego Herrera, AB Singleton, Priya Moorjani, Nelson B. Freimer, Ben A. Oostra, Peter Heutink, Shaun Purcell, Guy A. Rouleau, Cathy L. Budman, David V. Conti, Anna Tikhomirov, John Hardy, S. C. Mesa Restrepo, Barbara Kremeyer, S. Davarya, Cornelia Illmann, Kenneth K. Kidd, Andrew Crenshaw, J.R. Kidd, J. C. Cardona Silgado, R. Kurlan, Chunyu Liu, Robert B. Weiss, Mary M. Robertson, A.J. Pakstis, A. V. Valencia Duarte, Thomas V. Fernandez, Roel A. Ophoff, Matthew W. State, Sylvain Chouinard, Cathy L. Barr, N. Phan, Eduardo Fournier, H. Müller, Nancy J. Cox, Nicholas T. Weiss, Varda Gross-Tsur, Eskin E, Roxana Romero, Jay A. Tischfield, J. R. Gibbs, Allan L. Naarden, J.H. Smit, Marco A. Grados, Anuar Konkashbaev, Chiara Sabatti, Melissa Parkin, Christopher K. Edlund, Carol A. Mathews, Ruth D. Bruun, Joseph Jankovic, Donald L. Gilbert, Fortu Benarroch, Victor I. Reus, Michael Wagner, Jeremiah M. Scharf, Dongmei Yu, Danielle C. Cath, Benjamin M. Neale, Yehuda Pollak |
---|---|
Přispěvatelé: | Psychiatry, Human genetics, NCA - Brain mechanisms in health and disease, NCA - Neurobiology of mental health, Functional Genomics, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, Child and Adolescent Psychiatry / Psychology, Clinical Genetics |
Rok vydání: | 2013 |
Předmět: |
Male
DISORDER Obsessive-Compulsive Disorder Fibrillar Collagens International Cooperation Genome-wide association study Tourette syndrome 0302 clinical medicine DEPENDENCE SCHIZOPHRENIA GWAS genetics Copy-number variation Genetics COPY NUMBER VARIANTS 0303 health sciences education.field_of_study SLITRK1 VAR321 tics COMMON VARIANTS Ashkenazi jews 3. Good health FAMILY Psychiatry and Mental health Female Psychology Chromosomes Human Pair 9 Adult Tics Adolescent Genotype Population Tourette's syndrome Polymorphism Single Nucleotide White People Article 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult Meta-Analysis as Topic medicine Humans Genetic Predisposition to Disease 1000 Genomes Project education Molecular Biology 030304 developmental biology MUTATIONS POLR3B medicine.disease neurodevelopmental disorder INDIVIDUALS Attention Deficit Disorder with Hyperactivity Case-Control Studies 030217 neurology & neurosurgery Imputation (genetics) Genome-Wide Association Study Tourette Syndrome |
Zdroj: | Scharf, J M, Yu, D, Mathews, C A, Neale, B M, Stewart, S E, Fagerness, J A, Evans, P, Gamazon, E R, Edlund, C K, Service, S K, Tikhomirov, A, Osiecki, L, Illmann, C, Pluzhnikov, A, Konkashbaev, A I, Davis, L K, Han, B, Crane, J, Moorjani, P, Crenshaw, A T, Parkin, M A, Reus, V I, Lowe, T L, Rangel-Lugo, M, Chouinard, S, Dion, Y, Girard, S, Cath, D C, Smit, J H, King, R A, Fernandez, T V, Leckman, J F, Kidd, K K, Kidd, J R, Pakstis, A J, State, M W, Herrera, L D, Romero, R, Fournier, E, Sandor, P, Barr, C L, Phan, N, Gross-Tsur, V, Benarroch, F, Pollak, Y, Budman, C L, Bruun, R D, Erenberg, G, Naarden, A L, Lee, P C, Weiss, N, Kremeyer, B, Berrio, G B, Campbell, D D, Cardona Silgado, J C, Ochoa, W C, Mesa Restrepo, S C, Muller, H, Valencia Duarte, A V, Lyon, G J, Leppert, M, Morgan, J, Weiss, R, Grados, M A, Anderson, K, Davarya, S, Singer, H, Walkup, J, Jankovic, J, Tischfield, J A, Heiman, G A, Gilbert, D L, Hoekstra, P J, Robertson, M M, Kurlan, R, Liu, C, Gibbs, J R, Singleton, A, Hardy, J, Strengman, E, Ophoff, R A, Wagner, M, Moessner, R, Mirel, D B, Posthuma, D, Sabatti, C, Eskin, E, Conti, D V, Knowles, J A, Ruiz-Linares, A, Rouleau, G A, Purcell, S, Heutink, P, Oostra, B A, McMahon, W M, Freimer, N B, Cox, N J & Pauls, D L 2013, ' Genome-wide association study of Tourette's syndrome ', Molecular Psychiatry, vol. 18, no. 6, pp. 721-728 . https://doi.org/10.1038/mp.2012.69 Molecular psychiatry Molecular Psychiatry, 18(6), 721-728. Nature Publishing Group Molecular Psychiatry, 18, 721-728. Nature Publishing Group |
ISSN: | 1359-4184 |
Popis: | Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (P |
Databáze: | OpenAIRE |
Externí odkaz: |