The significance of ectopic crypt formation in the differential diagnosis of colorectal polyps
| Autor: | Eun-Jung Lee, Eui Gon Youk, Sung-Min Chun, Do Sun Kim, Mi-Jung Kim, Doo Han Lee, Se-Jin Jang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Proto-Oncogene Proteins B-raf medicine.medical_specialty Pathology Histology Muscularis mucosae Adenoma Colon Biopsy DNA Mutational Analysis Crypt Colonic Polyps Biology medicine.disease_cause Gastroenterology BRAF Pathology and Forensic Medicine Diagnosis Differential Proto-Oncogene Proteins p21(ras) Traditional serrated adenoma Adenomatous Polyps Aberrant Crypt Foci Predictive Value of Tests Proto-Oncogene Proteins Internal medicine KRAS medicine Humans Aged Aged 80 and over Tumor size medicine.diagnostic_test Research General Medicine Middle Aged medicine.disease Tumor Burden Conventional adenoma Ectopic crypt formation Mutation ras Proteins Female Differential diagnosis |
| Zdroj: | Diagnostic Pathology |
| ISSN: | 1746-1596 |
| Popis: | Background Ectopic crypts, defined as abnormally positioned crypts that have lost their orientation toward the muscularis mucosae, have been suggested to be the best defining histologic feature of traditional serrated adenoma (TSA). However, the significance of ectopic crypt formation (ECF) in the distinction between TSA and conventional adenoma (CA) has rarely been studied. Methods We designed this study to determine if ECF can be found in CA and its presence is exclusive to TSA. We studied 107 TSAs and 191 CAs including 106 tubular adenomas (TAs), 66 tubulovillous adenomas (TVAs), and 19 villous adenomas (VAs). Results ECF was identified in most (79.4%) but not all TSAs. Additionally, ECF was not infrequent in CA (62 of 191, 32.5%), and its presence correlated with the presence of a villous component and larger tumor size (each p |
| Databáze: | OpenAIRE |
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