Iron overload increases hepatic development of Plasmodium yoelii in mice
| Autor: | Joseph Goma, Miltgen F, Laurent Rénia, Dominique Mazier |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Iron Overload Ratón Iron Biology Ferric Compounds Microbiology Mice In vivo parasitic diseases medicine Parasite hosting Animals Mice Inbred BALB C Plasmodium yoelii medicine.disease biology.organism_classification In vitro Malaria Quaternary Ammonium Compounds Red blood cell Infectious Diseases medicine.anatomical_structure Liver Immunology Ferric Animal Science and Zoology Parasitology medicine.drug |
| Zdroj: | Parasitology. 112 |
| ISSN: | 0031-1820 |
| Popis: | SummaryIron overload in BALB/c mice by treatment with ferric ammonium citrate promotes the hepatic development ofPlasmodium yoelii in vivoand invitro. This was the result of increased penetration of the parasite into hepatocytes since no effect was observed on parasite transformation or maturation. These results could explain why in endemic regions iron supplementation led, in certain studies, to an increase in clinical episodes of malaria and in the prevalence of malaria infection. |
| Databáze: | OpenAIRE |
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