Women awaken faster than men after electroencephalogram-monitored propofol sedation for colonoscopy: A prospective observational study
| Autor: | Christian Unzicker, Barbara Schultz, Mark Slottje, Andrea Riphaus, Vera Limbach, Carolin Keil, Christian Mentzel, Jan Bulla |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Intraoperative Neurophysiological Monitoring Sedation Colonoscopy Loading dose 03 medical and health sciences 0302 clinical medicine Patient satisfaction Medicine Humans Hypnotics and Sedatives General anaesthesia Prospective Studies Wakefulness Prospective cohort study Propofol Aged Aged 80 and over Sex Characteristics 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Electroencephalography Middle Aged Anesthesiology and Pain Medicine Anesthesia Anesthesia Recovery Period 030211 gastroenterology & hepatology Observational study Female medicine.symptom business medicine.drug |
| Zdroj: | European journal of anaesthesiology. 34(10) |
| ISSN: | 1365-2346 |
| Popis: | Background Sedation for colonoscopy using intravenous propofol has become standard in many Western countries. Objective Gender-specific differences have been shown for general anaesthesia in dentistry, but no such data existed for gastrointestinal endoscopy. Design A prospective observational study. Setting An academic teaching hospital of Hannover Medical School. Patients A total of 219 patients (108 women and 111 men) scheduled for colonoscopy. Intervention Propofol sedation using electroencephalogram monitoring during a constant level of sedation depth (D0 to D2) performed by trained nurses or physicians after a body-weight-adjusted loading dose. Main outcome measures The primary end-point was the presence of gender-specific differences in awakening time (time from end of sedation to eye-opening and complete orientation); secondary outcome parameters analysed were total dose of propofol, sedation-associated complications (bradycardia, hypotension, hypoxaemia and apnoea), patient cooperation and patient satisfaction. Multivariate analysis was performed to correct confounding factors such as age and BMI. Results Women awakened significantly faster than men, with a time to eye-opening of 7.3 ± 3.7 versus 8.4 ± 3.4 min (P = 0.005) and time until complete orientation of 9.1 ± 3.9 versus 10.4 ± 13.7 min (P = 0.008). The propofol dosage was not significantly different, with some trend towards more propofol per kg body weight in women (3.98 ± 1.81 mg versus 3.72 ± 1.75 mg, P = 0.232). Conclusion The effect of gender aspects should be considered when propofol is used as sedation for gastrointestinal endoscopy. That includes adequate dosing for women as well as caution regarding potential overdosing of male patients. Trial registration ClinicalTrials.gov (Identifier: NCT02687568). |
| Databáze: | OpenAIRE |
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