| Autor: |
Kehili, Sarah, Boukhatem, Mohamed Nadjib, Belkadi, Asma, Ferhat, Mohamed Amine, Setzer, William N. |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
European Journal of Biological Research, Vol 10, Iss 2 (2020) |
| DOI: |
10.5281/zenodo.3831042 |
| Popis: |
The present investigation was designed to study the chemical composition of Algerian peppermint essential oil (PEO) as well as the in vitro and in vivo anti-inflammatory, wound-healing and anti-nociceptive properties. Twenty-three compounds were identified in the PEO with the main chemical component as menthol (53.29%). Also, PEO showed a high content of oxygenated monoterpene compounds (92.75%). Topical application of PEO at doses of 200 and 20 µL/kg significantly reduced the acute ear edema in 38.09% and 36.50, respectively. Histological observation confirmed that PEO inhibited the skin inflammatory response. In-vivo wound healing activity of the cream prepared from PEO (0.5% w/w) was assessed by circular excision wound model followed by histological examination. The topical administration of PEO cream showed a significant decrease of unhealed wound area rate between the 6th (1.67±0.14 mm2) and the 9th (0.49±0.22 mm2) days of treatment when compared with the vehicle (2.32±0.77 mm2; p2; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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