Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
| Autor: | Agnieszka Dansonka-Mieszkowska, Jerzy Stachura, Marrit Sarlomo-Rikala, Regine Schneider-Stock, Janusz Kopczyński, Jerzy Lasota, Janusz Limon, Tomoko Mitsuhashi, Jeffrey R. Lee, Agnieszka Wozniak, Bartek Wasag, Markku Miettinen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Genetic Markers Male Pathology medicine.medical_specialty Gastrointestinal Stromal Tumors Chromosomes Human Pair 22 Loss of Heterozygosity Locus (genetics) PDGFRA Biology Polymerase Chain Reaction Pathology and Forensic Medicine Loss of heterozygosity 03 medical and health sciences 0302 clinical medicine medicine Humans Gastrointestinal stromal tumors (GISTs) neoplasms Molecular Biology Aged 030304 developmental biology Aged 80 and over 0303 health sciences Chromosome Mapping Electrophoresis Capillary Chromosome Karyotype Cell Biology Middle Aged medicine.disease Immunohistochemistry digestive system diseases Tumor progression Karyotyping 030220 oncology & carcinogenesis Female Chromosome Deletion Stromal Cells Chromosome 22 Microsatellite Repeats |
| Zdroj: | Laboratory Investigation. 85:237-247 |
| ISSN: | 0023-6837 |
| Popis: | Mutational activation of KIT or PDGFRA is considered an early step in pathogenesis of gastrointestinal stromal tumors (GISTs); however, other nonrandom genetic changes have also been identified. At least three common regions of deletions on chromosome 22q, which may harbor putative tumor suppressor genes, have been defined. However, mapping of these regions has been inconsistent. It has also been speculated that GI autonomous nerve tumors (GANTs), GISTs with ultrastructural features suggestive of autonomic nerve differentiation, are characterized by a specific deletion involving 22q13 cytogenetic region. This study was undertaken to evaluate loss of heterozygosity (LOH) on chromosome 22q in 50 GISTs, including 10 GANTs. Four tumors were incidental minimal lesions |
| Databáze: | OpenAIRE |
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