Assessment of formulated amodiaquine microparticles inLeishmania donovaniinfected rats
| Autor: | Alexander K. Nyarko, Barima A. Afrane, Grace Lovia Allotey-Babington, Henrietta Annor, Marisa Nyarkoa Broni, Clement Sasu, N'guessan Benoit Banga, Kwame Hanson, Anoa Aidoo, Seth Kwabena Amponsah, Henry Darko, Isaac Somuah, Henry Nettey |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Drug
Drug Compounding media_common.quotation_subject Antiprotozoal Agents Leishmania donovani Pharmaceutical Science Capsules Bioengineering 02 engineering and technology Amodiaquine Pharmacology 030226 pharmacology & pharmacy Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Colloid and Surface Chemistry Pharmacokinetics parasitic diseases medicine Animals Physical and Theoretical Chemistry media_common biology Chemistry Organic Chemistry 021001 nanoscience & nanotechnology biology.organism_classification Leishmaniasis Visceral Female 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Microencapsulation. 34:21-28 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.1080/02652048.2017.1280094 |
| Popis: | The aim of this study was to formulate, characterise and evaluate the activity of amodiaquine microparticles against Leishmania donovani. Microparticles were formulated by encapsulating the drug in bovine serum albumin using the spray-dryer method. The microparticles were evaluated for size, zeta potential, drug content, encapsulation efficiency and in vitro release profile. The size range of the microparticles formulated was between 1.9 and 10 μm with an average zeta potential of -25.5 mV. Of the expected 20% drug loading, an average of 18.27% was obtained giving an encapsulation efficiency of 91.35%. Pharmacokinetic profile of amodiaquine improved with microencapsulation of the drug with C |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |