Dietary Salba (Salvia hispanica L) improves the altered metabolic fate of glucose and reduces increased collagen deposition in the heart of insulin-resistant rats
| Autor: | Adriana Benmelej, Noelia Villafañe, Yolanda B. Lombardo, Agustina Creus |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
0301 basic medicine medicine.medical_specialty Sucrose Otras Ciencias Biológicas medicine.medical_treatment Clinical Biochemistry DYSLIPIDEMIA 030209 endocrinology & metabolism Carbohydrate metabolism Biology Ciencias Biológicas 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Dietary Sucrose CARDIAC MUSCLE Internal medicine medicine Animals Salvia Beta oxidation GLUCOSE METABOLISM Dyslipidemias chemistry.chemical_classification 030109 nutrition & dietetics Insulin food and beverages Fatty acid SALVIA HISPANICA L Heart Cell Biology Lipid Metabolism medicine.disease Rats Glucose Endocrinology chemistry Biochemistry Seeds Collagen Insulin Resistance CIENCIAS NATURALES Y EXACTAS Corn oil INSULIN RESISTANCE |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 121:30-39 |
| ISSN: | 0952-3278 |
| Popis: | This study reports the effects of dietary Salba (chia) seeds on the mechanisms underlying impaired glucose metabolism in the heart of dyslipemic insulin-resistant rats fed a sucrose-rich diet (SRD). Wistar rats were fed a SRD for 3 months. Afterwards, half the animals continued with the SRD; in the other half's diet chia seeds replaced corn oil (CO) for three months (SRD+chia). In the control group, corn starch replaced sucrose. The replacement of CO by chia seeds in the SRD restored the activities of key enzymes involved in heart glucose metabolism decreasing fatty acid oxidation. Chia seeds normalized insulin stimulated GLUT-4 transporter, the abundance of IRS-1 and pAMPK, changed the profile of fatty acid phospholipids, reduced left-ventricle collagen deposition and normalized hypertension and dyslipidemia. New evidence is provided concerning the effects of dietary chia seeds in improving the altered metabolic fate of glucose in the heart of dyslipemic insulin-resistant rats. Fil: Creus, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina Fil: Benmelej, Adriana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina Fil: Villafañe, Roxana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina Fil: Lombardo, Yolanda B.. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina |
| Databáze: | OpenAIRE |
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