Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis
Autor: | Giuseppe Banfi, Elena De Vecchi, Emanuela Galliera, Massimiliano Marco Corsi Romanelli, Luca Massaccesi, Vincenza Ragone |
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Přispěvatelé: | Galliera, E, Massaccesi, L, Banfi, G, De Vecchi, E, Ragone, V, Romanelli, Mmc |
Rok vydání: | 2021 |
Předmět: |
chemistry.chemical_classification
Reactive oxygen species Osteolysis business.industry Endocrinology Diabetes and Metabolism Inflammatory response Osteoblast Inflammation medicine.disease medicine.disease_cause Bone resorption Implant integration Bone remodeling Endocrinology medicine.anatomical_structure chemistry Oxidative stress medicine Cancer research Periprosthetic osteolysis Orthopedics and Sports Medicine Implant medicine.symptom business |
Zdroj: | Clinical Reviews in Bone and Mineral Metabolism. 19:14-23 |
ISSN: | 1559-0119 1534-8644 |
DOI: | 10.1007/s12018-021-09278-7 |
Popis: | The success of implant performance and arthroplasty is based on several factors, including oxidative stress-induced osteolysis. Oxidative stress is a key factor of the inflammatory response. Implant biomaterials can release wear particles which may elicit adverse reactions in patients, such as local inflammatory response leading to tissue damage, which eventually results in loosening of the implant. Wear debris undergo phagocytosis by macrophages, inducing a low-grade chronic inflammation and reactive oxygen species (ROS) production. In addition, ROS can also be directly produced by prosthetic biomaterial oxidation. Overall, ROS amplify the inflammatory response and stimulate both RANKL-induced osteoclastogenesis and osteoblast apoptosis, resulting in bone resorption, leading to periprosthetic osteolysis. Therefore, a growing understanding of the mechanism of oxidative stress-induced periprosthetic osteolysis and anti-oxidant strategies of implant design as well as the addition of anti-oxidant agents will help to improve implants’ performances and therapeutic approaches. |
Databáze: | OpenAIRE |
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