Prognostic Value of microRNA 502 Binding Site SNP in the 3′-Untranslated Region of the SET8 Gene in Patients with Non-Hodgkin's Lymphoma
| Autor: | Lanping, Diao, Huiling, Su, Guangchuan, Wei, Tao, Li, Yuhuan, Gao, Guimin, Zhao, Zhanjun, Guo |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research Adolescent Kaplan-Meier Estimate Polymorphism Single Nucleotide Young Adult 03 medical and health sciences 0302 clinical medicine Humans Genetic Predisposition to Disease 3' Untranslated Regions Genetic Association Studies Aged Proportional Hazards Models Aged 80 and over Binding Sites Lymphoma Non-Hodgkin Histone-Lysine N-Methyltransferase General Medicine Middle Aged Prognosis Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female RNA Interference |
| Zdroj: | Tumori Journal. 100:553-558 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/1660.18180 |
| Popis: | A number of important cancer-associated covalent modifications of histone genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3'-untranslated regions. We evaluated the effect of single-nucleotide polymorphisms (SNPs) at the miR-502 binding site in the 3'-untranslated region of the SET8 gene on the clinical outcome of non-Hodgkin's lymphomas (NHL).The miR-502 binding site SNP of rs16917496 in the 3'-untranslated region of SET8 was genotyped with the ligation detection reaction method. The association of rs16917496 with NHL survival was calculated with the log-rank test using the Kaplan-Meier method. Multivariate survival analysis was performed using a Cox proportional hazards model.Patients carrying the rs16917496 CC genotype had a significantly longer survival time than patients carrying the CT genotype (P = 0.043) or TT genotype (P = 0.086). In addition, rs16917496 was associated independently with the survival of NHL patients in multivariate analysis (CC vs TT, 95% CI: 1.021-3.279, RR: 1.829, P = 0.043; CC vs CT, 95% CI: 1.026-3.339, RR: 1.851, P = 0.041). The association of rs16917496 with NHL survival was further identified in the peripheral T cell lymphoma (pTCL) subtype of NHL at borderline statistically significant levels (P = 0.069).Our study provides evidence that the SNP in the miRNA binding site of the SET8 3'-untranslated region seems to influence survival of NHL. It may have possible prognostic and survival value in the clinic. |
| Databáze: | OpenAIRE |
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