Effect of LLLT Ga–Al–As (685 nm) on LPS-induced inflammation of the airway and lung in the rat
| Autor: | Renato Amaro Zângaro, R. Albertine, Maria Cristina Chavantes, R. G. de. Magalhães, Rodrigo Álvaro Brandão Lopes-Martins, M.T.T. Pacheco, Hugo C. Castro-Faria-Neto, Flavio Aimbire |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Lipopolysaccharides
Male Pathology medicine.medical_specialty Neutrophils medicine.medical_treatment Inflammation Dermatology Pharmacology Sensitivity and Specificity Dinoprostone Random Allocation Reference Values medicine Animals Low-Level Light Therapy Low level laser therapy Probability Sulfonamides Lung medicine.diagnostic_test business.industry Chemotaxis Pneumonia respiratory system Rats respiratory tract diseases Trachea Chemotaxis Leukocyte Disease Models Animal Bronchoalveolar lavage medicine.anatomical_structure Celecoxib Pyrazoles lipids (amino acids peptides and proteins) Surgery Methacholine Bronchial Hyperreactivity Inflammation Mediators medicine.symptom business Airway Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Lasers in Medical Science. 20:11-20 |
| ISSN: | 1435-604X 0268-8921 |
| DOI: | 10.1007/s10103-005-0339-9 |
| Popis: | The purpose of this study was to investigate the effect of low level laser therapy (LLLT) on male Wistar rat trachea hyperreactivity (RTHR), bronchoalveolar lavage (BAL) and lung neutrophils influx after Gram-negative bacterial lipopolyssacharide (LPS) intravenous injection. The RTHR, BAL and lung neutrophils influx were measured over different intervals of time (90 min, 6 h, 24 h and 48 h). The energy density (ED) that produced an anti-inflammatory effect was 2.5 J/cm(2), reducing the maximal contractile response and the sensibility of trachea rings to methacholine after LPS. The same ED produced an anti-inflammatory effect on BAL and lung neutrophils influx. The Celecoxib COX-2 inhibitor reduced RTHR and the number of cells in BAL and lung neutrophils influx of rats treated with LPS. Celecoxib and LLLT reduced the PGE(2) and TXA(2) levels in the BAL of LPS-treated rats. Our results demonstrate that LLLT produced anti-inflammatory effects on RTHR, BAL and lung neutrophils influx in association with inhibition of COX-2-derived metabolites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink