Effect of recombinant human colony-stimulating factor on the course of parasitaemia in non-lethal rodent malaria
| Autor: | R. Kurihara, Mamoru Suzuki, H. Nemoto, Seiji Waki |
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| Rok vydání: | 1993 |
| Předmět: |
Plasmodium berghei
Injections Subcutaneous Parasitemia Granulocyte Antibodies Rodent Diseases Subcutaneous injection Interferon-gamma Mice Immunity Granulocyte Colony-Stimulating Factor medicine Animals General Veterinary biology Tumor Necrosis Factor-alpha fungi General Medicine Colony-stimulating factor biology.organism_classification medicine.disease Recombinant Proteins Granulocyte colony-stimulating factor Malaria Infectious Diseases medicine.anatomical_structure Insect Science Immunology Absolute neutrophil count Mice Inbred CBA Parasitology Female |
| Zdroj: | Parasitology research. 79(8) |
| ISSN: | 0932-0113 |
| Popis: | The effect of repeated subcutaneous injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the attenuated Plasmodium berghei XAT infection in CBA mice was examined. When mice were injected with rhG-CSF daily beginning 2 days before infection, the neutrophil count in the peripheral blood increased 5 times higher than that of control mice and the development of parasitaemia was suppressed significantly during the early phase of the infection. This suppressive effect of rhG-CSF was reduced by treatment of the mice with either anti-interferon (IFN)-gamma or anti-tumour necrosis factor (TNF)-alpha immunoglobulins. These results suggest that neutrophils may have a role in immunity against the parasites and that IFN-gamma and TNF-alpha are possibly involved. |
| Databáze: | OpenAIRE |
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