T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro
| Autor: | Maria Carmelita Maia e Silva, Maria Amélia Maciel, David Adam Plier, David O. Freedman |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cellular immunity Integrins Umbilical Veins Endothelium T-Lymphocytes Immunology Receptors Lymphocyte Homing Vascular Cell Adhesion Molecule-1 Inflammation Biology Integrin alpha4beta1 medicine.disease_cause Binding Competitive Pathology and Forensic Medicine Wuchereria Elephantiasis Filarial Antigen Cell Movement Receptors Very Late Antigen medicine Immunology and Allergy Animals Humans Wuchereria bancrofti NF-kappa B Antibodies Monoclonal T lymphocyte Lymphatic system medicine.anatomical_structure Female Endothelium Vascular medicine.symptom |
| Zdroj: | Clinical immunology and immunopathology. 82(3) |
| ISSN: | 0090-1229 |
| Popis: | The in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection. Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04). In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells. In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells. |
| Databáze: | OpenAIRE |
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