Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection

Autor: Anselmo Jiro Kamada, Telma Miyuki Oshiro, Alberto José da Silva Duarte, Sergio Crovella, Alessandra Pontillo, Martina Girardelli
Přispěvatelé: Pontillo, Alessandra, T. M., Oshiro, Girardelli, Martina, A. J., Kamada, Crovella, Sergio, A. J., S.
Rok vydání: 2012
Předmět:
Male
genetics
Caspase 1
Inflammasomes
Interleukin-1beta
genetics
Adult
Apoptosis Regulatory Protein
HIV Infections
Pathogenesis
Gene Frequency
NLRC4
genetics
Interleukin-1beta
genetics
Pharmacology (medical)
Genetics
NLRP1
Caspase 1
Intracellular Signaling Peptides and Proteins
genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HIV Infection
Adaptor Proteins
virus diseases
Inflammasome
Single Nucleotide
Middle Aged
genetics
Brazil
CARD Signaling Adaptor Protein
Neoplasm Proteins
Infectious Diseases
Female
medicine.symptom
Brazil
medicine.drug
Adult
Genotype
NLR Proteins
genetics
Polymorphism
Single-nucleotide polymorphism
Inflammation
Biology
Polymorphism
Single Nucleotide
genetics
Carrier Protein
genetics
Male
Middle Aged
Neoplasm Protein
genetics
Intracellular Signaling Peptides and Protein
NLR Family
Pyrin Domain-Containing 3 Protein
medicine
Humans
Genetic Predisposition to Disease
Polymorphism
genetics
Calcium-Binding Protein
Gene
Adaptor Proteins
Signal Transducing
Innate immune system
Calcium-Binding Proteins
Signal Transducing
genetics
HIV-1
Humans
Inflammasome
CARD Signaling Adaptor Proteins
genetics
Adult
Apoptosis Regulatory Proteins
genetics
Brazil
CARD Signaling Adaptor Proteins
genetics
Calcium-Binding Proteins
genetics
Carrier Proteins
genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HIV Infections
genetics
HIV-1
Humans
Inflammasomes
genetics
Intracellular Signaling Peptides and Proteins
genetics
Male
Middle Aged
Neoplasm Proteins
Adaptor Protein
Immunology
HIV-1
Apoptosis Regulatory Proteins
Carrier Proteins
Zdroj: JAIDS Journal of Acquired Immune Deficiency Syndromes. 59:121-125
ISSN: 1525-4135
DOI: 10.1097/qai.0b013e3182392ebe
Popis: The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
Databáze: OpenAIRE
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