The genetic structure of native Americans in North America based on the Globalfiler® STRs
| Autor: | Jessica A. Weise, Robert F. Oldt, Bruce Budowle, Jillian Ng, Sreetharan Kanthaswamy, Kelly L. McCulloh, David Glenn Smith, Joy Viray |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Population Population genetics Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Databases Genetic Humans 030216 legal & forensic medicine education Allele frequency health care economics and organizations education.field_of_study Chromosomes Human Y Geography Forensic Sciences Genetic data social sciences The arctic Forensic science Issues ethics and legal aspects Genetics Population 030104 developmental biology North America Genetic structure Indians North American Microsatellite geographic locations Microsatellite Repeats Demography |
| Zdroj: | Legal Medicine. 23:49-54 |
| ISSN: | 1344-6223 |
| Popis: | Current forensic STR databases, such as CODIS, lack population genetic data on Native American populations. Information from a geographically diverse array of tribes is necessary to provide improved statistical estimates of the strength of associations with DNA evidence. The Globalfiler® STR markers were used to characterize the genetic structure of ten tribal populations from seven geographic regions in North America, including those not presently represented in forensic databases. Samples from the Arctic region, Baja California, California/Great Basin, the Southeast, Mexico, the Midwest, and the Southwest were analyzed for allele frequencies, observed and expected heterozygosities, and F-statistics. The tribal samples exhibited an F ST or θ value above the conservative 0.03 estimate recommended by the National Research Council (NRC) for calculating random match probabilities among Native Americans. The greater differentiation among tribal populations computed here (θ=0.04) warrants the inclusion of additional regional Native American samples into STR databases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect