Acute uterine effects and long-term reproductive alterations in postnatally exposed female rats to a mixture of commercial formulations of endosulfan and glyphosate
| Autor: | Marlise Guerrero Schimpf, Paola I. Ingaramo, Jorgelina Varayoud, Maria Mercedes Milesi, Enrique H. Luque |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Insecticides
CIENCIAS MÉDICAS Y DE LA SALUD medicine.drug_class medicine.medical_treatment Glycine Uterus Ciencias de la Salud GLYPHOSATE Biology Toxicology UTERUS Andrology 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology PESTICIDE medicine FERTILITY Animals Rats Wistar Receptor Saline Endosulfan 030304 developmental biology 0303 health sciences Herbicides Proteins 04 agricultural and veterinary sciences General Medicine Pesticide 040401 food science Rats Otras Ciencias de la Salud medicine.anatomical_structure Animals Newborn chemistry Estrogen Glyphosate ENDOSULFAN Gestation Female Food Science |
| Zdroj: | Food and Chemical Toxicology. 134:110832 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2019.110832 |
| Popis: | Endosulfan and glyphosate are widely used pesticides and have been associated toreproductive disorders. We examine the acute and long-term effects of postnatal exposure to commercial formulations of endosulfan (EF), glyphosate (glyphosate-based herbicide, GBH) and a mixture of both pesticides (MIX). After birth, female pups of Wistar rats received saline solution (CONTROL), EF (600 µg/Kg of b.w/day), GBH (2 mg/Kg of b.w/day) or a mixture (at the same doses) from postnatal day (PND) 1 to PND7. The uterine histology and expression of Hoxa10, estrogen (ERα) and progesterone (PR) receptors were evaluated on PND8. Reproductive performance was evaluated on gestational day 19. GBH and MIX rats showed an increment of 1) the incidence of luminal epithelial hyperplasia, 2)PR and Hoxa10 expression. EF modified ERα and Hoxa10 expression. During adulthood, MIX and GBH rats showed higher post-implantation losses while EF alone produced an increase of pre-implantation losses. We showed that the co-administration of both pesticides produced acute uterine effects and long?term deleterious reproductive effects that were similar to those induced by GBH alone. We consider important to highlight the necessity to evaluate the commercial pesticide mixture as a more representative model of human exposure to a high number of pesticides. Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina Fil: Guerrero Schimpf, Marlise Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina Fil: Milesi, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina Fil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina Fil: Varayoud, Jorgelina Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina |
| Databáze: | OpenAIRE |
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