Intracranial Haemorrhage in Haemophilia Patients Is Still an Open Issue: The Final Results of the Italian EMO.REC Registry

Autor: Ezio Zanon, Samantha Pasca, Francesco Demartis, Annarita Tagliaferri, Cristina Santoro, Isabella Cantori, Angelo Claudio Molinari, Chiara Biasoli, Antonio Coppola, Matteo Luciani, Gianluca Sottilotta, Irene Ricca, Berardino Pollio, Alessandra Borchiellini, Alberto Tosetto, Flora Peyvandi, Anna Chiara Frigo, Paolo Simioni
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Clinical Medicine; Volume 11; Issue 7; Pages: 1969
ISSN: 2077-0383
DOI: 10.3390/jcm11071969
Popis: Background: Intracranial hemorrhage (ICH) is a highly serious event in patients with haemophilia (PWH) which leads to disability and in some cases to death. ICH occurs among all ages but is particularly frequent in newborns. Aim: The primary aim was to assess the incidence and mortality due to ICH in an Italian population of PWH. Secondary aims were to evaluate the risk factors for ICH, the role of prophylaxis, and the clinical management of patients presenting ICH. Methods: A retrospective-prospective registry was established in the network of the Italian Association of Haemophilia Centers to collect all ICHs in PWH from 2009 to 2019 reporting clinical features, treatments, and outcomes. Results: Forty-six ICHs were collected from 13 Centers. The ICHs occurred in 15 children (10 < 2 years), and in 31 adults, 45.2% of them with mild hemophilia. Overall, 60.9% patients had severe haemophilia (15/15 children). Overall ICH incidence (×1000 person/year) was 0.360 (0.270–0.480 95% CI), higher in children
Databáze: OpenAIRE
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