Effects ofLigustrum robustumon gut microbes and obesity in rats
| Autor: | Shan Liu, Zhi-Mei Xie, Lu Qi, Haojiang Zuo, Tao Zhou, Qian Ye, Hong-Yu Liao, Xiaofang Pei, Jing Huang |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Ligustrum robustum Ligustrum Adipose tissue Biology Pharmacology Diet High-Fat law.invention Rats Sprague-Dawley In vivo law Lactobacillus Weight Loss Animals Obesity Feces Adiposity Plants Medicinal Bacteria Traditional medicine Plant Extracts Gastroenterology General Medicine Basic Study biology.organism_classification Anti-Bacterial Agents Gastrointestinal Microbiome Intestines Disease Models Animal Real-time polymerase chain reaction Anti-Obesity Agents Phytotherapy |
| Zdroj: | World Journal of Gastroenterology. 21:13042 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v21.i46.13042 |
| Popis: | AIM: To investigate the anti-obesity and antibacterial effects of Ligustrum robustum (L. robustum) in vivo and in vitro and its possible mechanisms. METHODS: The effects of L. robustum aqueous extract (LR) on various gut bacteria in vitro were evaluated. The effects of LR on high-fat diet-fed (HFD) rats in vivo were also assessed. Culture methods, quantitative polymerase chain reaction, and terminal-restriction fragment length polymorphism were used to analyze the effects of LR on gut bacteria. Biochemical tests were also performed to detect the changes in obesity-related indicators after LR treatment. RESULTS: LR treatment lowered adipose weight and decreased Lee’s index, blood glucose, total cholesterol, and lipid in the tested groups relative to control (P < 0.05). To determine the reasons for these changes, we assessed the potential bacteriostatic and bactericidal effects of LR on specific bacterial species in vitro. LR affected the richness, diversity, and evenness of gut bacteria, increased fecal Lactobacillus, and decreased Enterococci in HFD rats (P < 0.05). CONCLUSION: L. robustum may be a safe and effective food for weight loss and obesity control, and the effects of L. robustum might be mediated by the regulation of gut bacteria. |
| Databáze: | OpenAIRE |
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