The effect of subcutaneous injection of methylprednisolone acetate and lidocaine for refractory postherpetic neuralgia: a prospective, observational study

Autor: Van Tuan Nguyen, Van Quan Le, Trung Duc Le, Quang An Nguyen, Thanh Chung Dang, Tien Ung Hoang, Thi Ngoc Truong Tran, Dinh Son Nhu, Minh Tuan Duong, Thi Dung Hoang, Ta Hai Ninh Duong, Duc Thuan Nguyen, Viet Nga Phan
Rok vydání: 2020
Předmět:
Zdroj: Health Science Reports
Health Science Reports, Vol 4, Iss 2, Pp n/a-n/a (2021)
ISSN: 2398-8835
Popis: Background Postherpetic neuralgia (PHN) is the most common and bearable complication of herpes zoster (HZ). This pain may have negative impact on the patient's all aspects of daily life and health‐related quality of life (HRQOL). Despite numerous advances in treatment, many patients remain resistant to the current therapy options. It is the first time subcutaneous injection of methylprednisolone acetate and lidocaine has been used to treat refractory PHN. We report the results of this treatment evaluating pain relief and HRQOL improvement in this disorder. Methods A total of 43 patients with refractory PHN was enrolled in the observational study. All patients received daily subcutaneous injection of methylprednisolone acetate and lidocaine for 10 consecutive days. The severity of pain was assessed by using Visual Analog Scale (VAS), and 36‐Item Short Form Survey (SF‐36) was applied to evaluate HRQOL. Assessment of the pain and HRQOL was carried out at baseline and posttreatment at 4 weeks as well as 6 and 12 months. Results At baseline, all patients experienced severe PHN with average VAS scores of 8.44 ± 0.85 (minimum 7; maximum 10). At 4 weeks, 6 months, and 12 months after treatment, the pain had significantly decreased (P
Databáze: OpenAIRE
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