Increased Urinary Levels of Pentosidine Measured by a Newly Developed Enzyme-Linked Immunosorbent Assay Are Independently Correlated with Fracture After Fall
| Autor: | Atsuko Tahara, Sachiyo Igata, Munehisa Bekki, Sho-ichi Yamagishi, Akihiro Honda, Ako Fukami, Shoko Maeda, Yoshihiro Fukumoto, Nobuhiro Tahara, Yoichi Sugiyama, Hanae Yoshimura, Takanori Matsui, Hisashi Adachi, Mika Enomoto, Yuri Nishino |
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| Rok vydání: | 2021 |
| Předmět: |
Aging
medicine.medical_specialty Urinary system Population Urology Enzyme-Linked Immunosorbent Assay Urine Arginine chemistry.chemical_compound Urinary levels Glycation Diabetes mellitus Medicine Humans Pentosidine education Aged education.field_of_study business.industry Lysine medicine.disease chemistry Biomarker (medicine) Accidental Falls Female Geriatrics and Gerontology business |
| Zdroj: | Rejuvenation research. 24(6) |
| ISSN: | 1557-8577 |
| Popis: | Although we have found that increased serum levels of glyceraldehyde-derived advanced glycation end products are associated with numerous aging-related disorders, it remains unclear which structurally distinct advanced glycation end products could be a reliable biomarker of the healthy life-threatening disorders. Since pentosidine is produced by glyceraldehyde, we measured here urinary pentosidine levels with a newly developed enzyme-linked immunosorbent assay kit, which requires no pretreatment with acid hydrolysis and heat, and examined their correlations with geriatric syndrome, such as musculoskeletal disease, frailty, and cognitive impairment, in a general population. Multiple regression analysis revealed that female, age, history of fracture after fall, and taking medication for diabetes were independent correlates of log urine pentosidine-to-creatinine ratio (R2=0.190). When sex-adjusted log urine pentosidine-to-creatinine ratio stratified by smile frequency grade were compared using analysis of covariance, urine pentosidine-to-creatinine ratio was significantly decreased according to the increase in smile frequency. Our present findings suggest that measurement of urine pentosidine-to-creatinine ratio by a newly developed enzyme-linked immunosorbent assay kit may be useful for identifying high-risk patients for fall-related fractures. |
| Databáze: | OpenAIRE |
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