Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy
| Autor: | Xiaoxuan Liu, Yanhua Zhang, Juan L Iovanna, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, Ling Peng, Yi Xia |
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| Přispěvatelé: | Chongqing University [Chongqing], ABiMS - Informatique et bioinformatique = Analysis and Bioinformatics for Marine Science (ABIMS), Fédération de recherche de Roscoff (FR2424), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), China Pharmaceutical University (CPU), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ABiMS - Informatique et bioinformatique = Analysis and Bioinformatics for Marine Science (FR2424), China Pharmaceut Univ, State Key Lab Nat Med, Ctr Drug Discovery, Ctr Adv Pharmaceut & Biomat, Nanjing 210009, Peoples R China, PENG, Ling |
| Rok vydání: | 2020 |
| Předmět: |
Programmed cell death
[CHIM.THER] Chemical Sciences/Medicinal Chemistry [SDV]Life Sciences [q-bio] Triazole Antineoplastic Agents Apoptosis [CHIM.THER]Chemical Sciences/Medicinal Chemistry Catalysis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Heat Shock Transcription Factors Cell Line Tumor Autophagy Materials Chemistry Humans ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences [CHIM.ORGA]Chemical Sciences/Organic chemistry Metals and Alloys Nucleosides General Chemistry Triazoles 3. Good health Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Biochemistry 030220 oncology & carcinogenesis Ceramics and Composites Microtubule-Associated Proteins Nucleoside |
| Zdroj: | Chemical Communications Chemical Communications, 2020, 56 (69), pp.10014-10017. ⟨10.1039/d0cc04660d⟩ Chemical Communications, Royal Society of Chemistry, 2020, 56 (69), pp.10014-10017. ⟨10.1039/d0cc04660d⟩ Chemical Communications, Royal Society of Chemistry, 2020, ⟨10.1039/d0cc04660d⟩ |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | International audience; Novel nucleoside derivatives were developed using the strategy of “terminal N,N-dimethylation” to impart tertiary amines to a 1,2,4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates. |
| Databáze: | OpenAIRE |
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