An African perspective on the genetic risk of chronic kidney disease: a systematic review

Autor: Tandi E. Matsha, François Kaze Folefack, Ikechi G. Okpechi, Yandiswa Y Yako, Andre Pascal Kengne, Cindy George
Přispěvatelé: Division of Nephrology and Hypertension, Faculty of Health Sciences
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Apolipoprotein L1
030232 urology & nephrology
Gene Expression
Bioinformatics
urologic and male genital diseases
End-stage renal disease
0302 clinical medicine
Gene Frequency
Chronic kidney disease
Genetics (clinical)
education.field_of_study
biology
female genital diseases and pregnancy complications
Female
Adiponectin
Research Article
Risk
lcsh:Internal medicine
Nitric Oxide Synthase Type III
lcsh:QH426-470
Receptors
CCR2
Population
Black People
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
End stage renal disease
03 medical and health sciences
Apolipoproteins E
medicine
Genetics
Humans
Renal Insufficiency
Chronic
education
lcsh:RC31-1245
Monoamine Oxidase
Alleles
Genetic association
Xeroderma Pigmentosum Group D Protein
business.industry
Haplotype
medicine.disease
lcsh:Genetics
030104 developmental biology
X-ray Repair Cross Complementing Protein 1
Haplotypes
Methylenetetrahydrofolate reductase
Africa
biology.protein
Kidney Failure
Chronic
business
Kidney disease
Genome-Wide Association Study
Zdroj: BMC Medical Genetics
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-15 (2018)
Popis: Background Individuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking. Methods We conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) with prevalent CKD, end-stage renaldisease (ESRD) or CKD-associated traits. Given the very few studies investigating the effects of the same single nucleotide polymorphisms (SNPs) on CKD risk, a narrative synthesis of the evidence was conducted. Results A total of 30 polymorphisms in 11 genes were investigated for their association with CKD, ESRD or related traits, all using the candidate-gene approach. Of all the included genes, MYH9, AT1R and MTHFR genes failed to predict CKD or related traits, while variants in the APOL1, apoE, eNOS, XPD, XRCC1, renalase, ADIPOQ, and CCR2 genes were associated with CKD or other related traits. Two SNPs (rs73885319, rs60910145) and haplotypes (G-A-G; G1; G2) of the apolipoprotein L1 (APOL1) gene were studied in more than one population group, with similar association with prevalent CKD observed. The remaining polymorphisms were investigated in single studies. Conclusion According to this systematic review, there is currently insufficient evidence of the specific polymorphisms that poses African populations at an increased risk of CKD. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms, specific to African populations.
Databáze: OpenAIRE
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