Leucine-Rich Repeat Protein Complex Activates Mosquito Complement in Defense Against Plasmodium Parasites

Autor: Fotis C. Kafatos, Michael Povelones, George K. Christophides, Robert M. Waterhouse
Rok vydání: 2009
Předmět:
Plasmodium berghei
Anopheles gambiae
Amino Acid Motifs
Leucine/chemistry
Genes
Insect
Complement C3/immunology/metabolism
Leucine-rich repeat
Article
Microbiology
Apicomplexa
Immune system
Leucine
Hemolymph
Anopheles
parasitic diseases
Animals
Insect Proteins/chemistry/genetics/isolation & purification/metabolism
ddc:576.5
Gene Silencing
Complement Activation
Multidisciplinary
biology
Effector
fungi
Insect Vectors/genetics/immunology/metabolism/parasitology
Complement C3
Plasmodium berghei/immunology/physiology
biology.organism_classification
Virology
Insect Vectors
Complement system
Multiprotein Complexes
Gene Knockdown Techniques
Anopheles gambiae/genetics/immunology/metabolism/parasitology
Insect Proteins
Protozoa
Female
Multiprotein Complexes/chemistry/metabolism
Digestive System/parasitology
Digestive System
Zdroj: Science, Vol. 324, No 5924 (2009) pp. 258-61
ISSN: 1095-9203
0036-8075
Popis: Leucine-rich repeat–containing proteins are central to host defense in plants and animals. We show that in the mosquito Anopheles gambiae , two such proteins that antagonize malaria parasite infections, LRIM1 and APL1C, circulate in the hemolymph as a high-molecular-weight complex held together by disulfide bridges. The complex interacts with the complement C3-like protein, TEP1, promoting its cleavage or stabilization and its subsequent localization on the surface of midgut-invading Plasmodium berghei parasites, targeting them for destruction. LRIM1 and APL1C are members of a protein family with orthologs in other disease vector mosquitoes and appear to be important effectors in innate mosquito defenses against human pathogens.
Databáze: OpenAIRE
Externí odkaz: