Variable glycemic responses to intact and hydrolysed milk proteins in overweight and obese adults reveal the need for precision nutrition
| Autor: | Katy Horner, Victoria O’Sullivan, Richard J. FitzGerald, Alice B. Nongonierma, Aoife M. Curran, Lorraine Brennan, Eoin G. Murphy, Phil M. Kelly, Solène Le Maux |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male Medicine (miscellaneous) Physiology Overweight Hydrolysate Inter-individual responses Glucose monitoring medicine Humans Ingestion Precision Medicine Glycemic Cross-Over Studies Nutrition and Dietetics business.industry Repeated measures design Precision nutrition Middle Aged Milk Proteins Crossover study Postprandial Postprandial glycemic response Female Nutrition Therapy medicine.symptom business Body mass index |
| Popis: | Background Dietary modifications can contribute to improved pancreatic β cell function and enhance glycemic control. Objectives The objectives of this study were as follows: 1) to investigate the potential of milk protein hydrolysates to modulate postprandial glucose response; 2) to assess individual responses; and 3) to explore the inter- and intraindividual reproducibility of the response. Methods A 14-d randomized crossover study investigated interstitial glucose levels of participants in response to 12% w/v milk protein drinks (intact caseinate and casein hydrolysate A and B) consumed in random order with a 2-d washout between treatments. Milk protein drinks were consumed immediately prior to study breakfast and evening meals. Twenty participants (11 men, 9 women) aged 50 ± 8 y with a body mass index (in kg/m2) of 30.2 ± 3.1 were recruited. Primary outcome was glucose levels assessed at 15-min intervals with the use of glucose monitors. Results Repeated-measures ANOVA revealed that for breakfast there was a significant difference across the 3 treatment groups (P = 0.037). The ability to reduce postprandial glucose was specific to casein hydrolysate B in comparison with intact caseinate (P = 0.039). However, despite this significant difference, further examination revealed that only 3 out of 18 individuals were classified as responders (P |
| Databáze: | OpenAIRE |
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