Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
Autor: | E. Huisman, Wilma D.J. van de Berg, Afina W. Lemstra, Madhurima Chatterjee, Inger van Steenoven, Wiesje M. van der Flier, Charlotte E. Teunissen, Marta Del Campo, Linda Oosterveld, Henk W. Berendse |
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Přispěvatelé: | Clinical chemistry, Amsterdam Neuroscience - Neurodegeneration, Anatomy and neurosciences, Neurology, APH - Methodology, APH - Personalized Medicine, Amsterdam Reproduction & Development (AR&D) |
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Pathology Parkinson's disease lcsh:QR1-502 Hippocampus Biochemistry lcsh:Microbiology Pathogenesis 0302 clinical medicine Cerebrospinal fluid Entorhinal Cortex Medicine Parkinson Disease Middle Aged cerebrospinal fluid (CSF) biomarker Parkinson’s disease (PD) contactin Substantia Nigra alpha-Synuclein biomarker Female Autopsy Lewy Body Disease Contactin 1 medicine.medical_specialty Parkinson’s disease (PD) dementia with Lewy bodies (DLB) synaptic degeneration Down-Regulation tau Proteins cerebrospinal fluid (CSF) Substantia nigra Article Protein Aggregates 03 medical and health sciences Contactin 2 Humans Molecular Biology Aged dementia with Lewy bodies (DLB) business.industry Dementia with Lewy bodies medicine.disease Entorhinal cortex nervous system diseases 030104 developmental biology Case-Control Studies Linear Models Lewy bodies business 030217 neurology & neurosurgery |
Zdroj: | Biomolecules, 10(8):1177, 1-15. Multidisciplinary Digital Publishing Institute (MDPI) Chatterjee, M, van Steenoven, I, Huisman, E, Oosterveld, L, Berendse, H, van der Flier, W M, del Campo, M, Lemstra, A W, van de Berg, W D J & Teunissen, C E 2020, ' Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies ', Biomolecules, vol. 10, no. 8, 1177, pp. 1-15 . https://doi.org/10.3390/biom10081177 Biomolecules Volume 10 Issue 8 Biomolecules, Vol 10, Iss 1177, p 1177 (2020) |
ISSN: | 2218-273X |
Popis: | Synaptic degeneration is an early phenomenon in Parkinson&rsquo s disease (PD) pathogenesis. We aimed to investigate whether levels of synaptic proteins contactin-1 and contactin-2 in cerebrospinal fluid (CSF) of PD patients are reduced compared to dementia with Lewy bodies (DLB) patients and controls and to evaluate their relationship with &alpha synuclein aggregation. Contactin-1 and -2 were measured in CSF from PD patients (n = 58), DLB patients (n = 72) and age-matched controls (n = 90). Contactin concentration differences between diagnostic groups were assessed by general linear models adjusted for age and sex. Contactin immunoreactivity was characterized in postmortem substantia nigra, hippocampus and entorhinal cortex tissue of PD patients (n = 4) and controls (n = 4), and its relation to &alpha syn aggregation was evaluated using confocal laser scanning microscopy. Contactin-1 levels were lower in PD patients (42 (36&ndash 49) pg/mL) compared to controls (52 (44&ndash 58) pg/mL, p = 0.003) and DLB patients (56 (46&ndash 67) pg/mL, p = 0.001). Contactin-2 levels were similar across all diagnostic groups. Within the PD patient group, contactin-1 correlated with t-&alpha syn, tTau and pTau (r = 0.30&ndash 0.50, p < 0.05), whereas contactin-2 only correlated with t-&alpha syn (r = 0.34, p = 0.03). Contactin-1 and -2 were observed within nigral and cortical Lewy bodies and clustered within bulgy Lewy neurites in PD brains. A decrease in CSF contactin-1 may reflect synaptic degeneration underlying Lewy body pathology in PD. |
Databáze: | OpenAIRE |
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