Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies

Autor: E. Huisman, Wilma D.J. van de Berg, Afina W. Lemstra, Madhurima Chatterjee, Inger van Steenoven, Wiesje M. van der Flier, Charlotte E. Teunissen, Marta Del Campo, Linda Oosterveld, Henk W. Berendse
Přispěvatelé: Clinical chemistry, Amsterdam Neuroscience - Neurodegeneration, Anatomy and neurosciences, Neurology, APH - Methodology, APH - Personalized Medicine, Amsterdam Reproduction & Development (AR&D)
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Pathology
Parkinson's disease
lcsh:QR1-502
Hippocampus
Biochemistry
lcsh:Microbiology
Pathogenesis
0302 clinical medicine
Cerebrospinal fluid
Entorhinal Cortex
Medicine
Parkinson Disease
Middle Aged
cerebrospinal fluid (CSF)
biomarker
Parkinson’s disease (PD)
contactin
Substantia Nigra
alpha-Synuclein
biomarker
Female
Autopsy
Lewy Body Disease
Contactin 1
medicine.medical_specialty
Parkinson’s disease (PD)
dementia with Lewy bodies (DLB)
synaptic degeneration
Down-Regulation
tau Proteins
cerebrospinal fluid (CSF)
Substantia nigra
Article
Protein Aggregates
03 medical and health sciences
Contactin 2
Humans
Molecular Biology
Aged
dementia with Lewy bodies (DLB)
business.industry
Dementia with Lewy bodies
medicine.disease
Entorhinal cortex
nervous system diseases
030104 developmental biology
Case-Control Studies
Linear Models
Lewy bodies
business
030217 neurology & neurosurgery
Zdroj: Biomolecules, 10(8):1177, 1-15. Multidisciplinary Digital Publishing Institute (MDPI)
Chatterjee, M, van Steenoven, I, Huisman, E, Oosterveld, L, Berendse, H, van der Flier, W M, del Campo, M, Lemstra, A W, van de Berg, W D J & Teunissen, C E 2020, ' Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies ', Biomolecules, vol. 10, no. 8, 1177, pp. 1-15 . https://doi.org/10.3390/biom10081177
Biomolecules
Volume 10
Issue 8
Biomolecules, Vol 10, Iss 1177, p 1177 (2020)
ISSN: 2218-273X
Popis: Synaptic degeneration is an early phenomenon in Parkinson&rsquo
s disease (PD) pathogenesis. We aimed to investigate whether levels of synaptic proteins contactin-1 and contactin-2 in cerebrospinal fluid (CSF) of PD patients are reduced compared to dementia with Lewy bodies (DLB) patients and controls and to evaluate their relationship with &alpha
synuclein aggregation. Contactin-1 and -2 were measured in CSF from PD patients (n = 58), DLB patients (n = 72) and age-matched controls (n = 90). Contactin concentration differences between diagnostic groups were assessed by general linear models adjusted for age and sex. Contactin immunoreactivity was characterized in postmortem substantia nigra, hippocampus and entorhinal cortex tissue of PD patients (n = 4) and controls (n = 4), and its relation to &alpha
syn aggregation was evaluated using confocal laser scanning microscopy. Contactin-1 levels were lower in PD patients (42 (36&ndash
49) pg/mL) compared to controls (52 (44&ndash
58) pg/mL, p = 0.003) and DLB patients (56 (46&ndash
67) pg/mL, p = 0.001). Contactin-2 levels were similar across all diagnostic groups. Within the PD patient group, contactin-1 correlated with t-&alpha
syn, tTau and pTau (r = 0.30&ndash
0.50, p <
0.05), whereas contactin-2 only correlated with t-&alpha
syn (r = 0.34, p = 0.03). Contactin-1 and -2 were observed within nigral and cortical Lewy bodies and clustered within bulgy Lewy neurites in PD brains. A decrease in CSF contactin-1 may reflect synaptic degeneration underlying Lewy body pathology in PD.
Databáze: OpenAIRE
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