Inverse gas chromatography a tool to follow physicochemical modifications of pharmaceutical solids: Crystal habit and particles size surface effects

Autor: Fabienne Espitalier, Rachel Calvet, Guadalupe Vaca-Medina, M. G. Cares-Pacheco, Antoine Rouilly
Přispěvatelé: Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique - CNRS (FRANCE), Ecole nationale supérieure des Mines d'Albi-Carmaux - IMT Mines Albi (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Chimie Agro-Industrielle (CAI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Rok vydání: 2015
Předmět:
Zdroj: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2015, 494 (1), pp.113-126. ⟨10.1016/j.ijpharm.2015.07.078⟩
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2015.07.078
Popis: International audience; Powders are complex systems and so pharmaceutical solids are not the exception. Nowadays, pharmaceutical ingredients must comply with well-defined draconian specifications imposing narrow particle size range, control on the mean particle size, crystalline structure, crystal habits aspect and surface properties of powders, among others. The different facets, physical forms, defects and/or impurities of the solid will alter its interaction properties. A powerful way of studying surface properties is based on the adsorption of an organic or water vapor on a powder. Inverse gas chromatography (IGC) appears as a useful method to characterize the surface properties of divided solids. The aim of this work is to study the sensitivity of IGC, in Henry's domain, in order to detect the impact of size and morphology in surface energy of two crystalline forms of an excipient, D-mannitol. Surface energy analyses using IGC have shown that the alpha form is the most energetically active form. To study size and shape influence on polymorphism, pure alpha and beta mannitol samples were cryomilled (CM) and/or spray dried (SD). All forms showed an increase of the surface energy after treatment, with a higher influence for beta samples (gamma(d)(s) of 40-62 mJ m(-2)) than for a mannitol samples (gamma(d)(s) of 75-86 mJ m(-2)). Surface heterogeneity analysis in Henry's domain showed a more heterogeneous beta-CM sample (62-52 mJ m(-2)). Moreover, despite its spherical shape and quite homogeneous size distribution, beta-SD mannitol samples showed a slightly heterogeneous surface (57-52 mJ m(-2)) also higher than the recrystallized beta pure sample (similar to 40 mJ m(-2)).
Databáze: OpenAIRE
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