Interleukin‐18 and tumor necrosis factor‐α are elevated in solid organ transplant recipients with possible cytomegalovirus end‐organ disease
Autor: | Alexis Figueroa, Stuart C. Ray, Seema Mehta Steinke, Andrew H. Karaba, Andrea L. Cox, Maria Veronica Dioverti, William A. Werbel, Robin K. Avery |
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Rok vydání: | 2021 |
Předmět: |
Congenital cytomegalovirus infection
Cytomegalovirus Disease Antiviral Agents Article Proinflammatory cytokine Biopsy Humans Medicine Transplantation medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Interleukin-18 virus diseases Interleukin Organ Transplantation medicine.disease Transplant Recipients Infectious Diseases Cytomegalovirus Infections Immunology Interleukin 18 Tumor necrosis factor alpha Serostatus business |
Zdroj: | Transpl Infect Dis |
ISSN: | 1399-3062 1398-2273 |
Popis: | End-organ cytomegalovirus (CMV) disease can be life threatening to solid organ transplant recipients. Diagnosis is often complicated by variation in amount of CMV DNA in plasma and the need for an invasive procedure to obtain a biopsy of the suspected affected organ, which can delay recognition and treatment. Several inflammatory cytokines are elevated in CMV disease, and the purpose of this study was to determine if they could be used to distinguish solid organ transplant recipients with CMV DNAemia alone from those with possible end-organ CMV disease. We found that regardless of pre-transplant CMV serostatus, plasma interleukin (IL)-18, tumor necrosis factor-α (TNF-α), and amount of CMV DNA in plasma were increased in possible end-organ CMV disease, with elevated IL-18 associated with increased odds of possible end-organ CMV disease even after adjusting for amount of CMV DNA. These findings highlight IL-18 and TNF-α as potential non-invasive markers of possible end-organ CMV disease regardless of transplanted organ or serostatus in solid organ transplant recipients. |
Databáze: | OpenAIRE |
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