An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques†
| Autor: | Nicola O’Reilly, John F.X. Diffley, Dhira Joshi, George Papageorgiou, Theresa U. Zeisner, Jennifer C. Milligan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences Ketone Protease 010405 organic chemistry Hydrochloride General Chemical Engineering Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.medical_treatment Improved method Peptide General Chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound Chemistry chemistry medicine Solid-Phase Peptide Synthesis Techniques Linker 030304 developmental biology |
| Zdroj: | Rsc Advances |
| ISSN: | 2046-2069 |
| Popis: | An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fmoc peptide procedures, a number of short Z-protected peptides were synthesised and assessed as possible inhibitors of the main protease from SARS-CoV-2 (3CLpro). An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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