Tissue plasminogen activator reduces brain injury in a rabbit model of thromboembolic stroke
| Autor: | Martin M. Bednar, Cordell E. Gross, Timothy L. McAuliffe, Sheila J. Raymond |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Intracranial Pressure medicine.medical_treatment Hemodynamics Hematocrit Tissue plasminogen activator Internal medicine Fibrinolysis medicine Animals Stroke Advanced and Specialized Nursing medicine.diagnostic_test business.industry Brain Arteries Carbon Dioxide Intracranial Embolism and Thrombosis medicine.disease Oxygen Cerebrovascular Disorders Cerebral blood flow Cerebrovascular Circulation Tissue Plasminogen Activator Anesthesia Cardiology Female Rabbits Neurology (clinical) Cardiology and Cardiovascular Medicine business Plasminogen activator medicine.drug |
| Zdroj: | Stroke. 21:1705-1709 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/01.str.21.12.1705 |
| Popis: | Tissue plasminogen activator is an endogenous fibrin-specific serine protease with potent thrombolytic activity. We investigated the efficacy of tissue plasminogen activator in reducing cerebral infarct size after thromboembolic stroke in a rabbit model. Seventeen rabbits were randomized to receive either tissue plasminogen activator (2.5 mg/kg, n = 6) or vehicle control (n = 11). We controlled mean arterial pressure, hematocrit, and arterial blood gases before and after the intracarotid embolization of an autologous clot. Cerebral blood flow (cm3/100 g/min) (mean +/- SEM) was immediately reduced from 55.2 +/- 7.7 to 8.5 +/- 2.5 in the control group and from 61.8 +/- 14.8 to 10.0 +/- 3.5 in the treated group after embolization. Cerebral blood flow recovered significantly within 60 minutes of thrombolytic therapy and attained a value of 59.6 +/- 10.0 cm3/100 g/min 4 hours after embolization, whereas cerebral blood flow in control animals demonstrated only a minimal recovery to 15.3 +/- 8.9 cm3/100 g/min. Cerebral infarct size (percent of hemisphere) was reduced from 34.4 +/- 5.6% in control animals to 8.8 +/- 5.6% in treated animals (mean +/- SEM, p less than 0.01). These results suggest that tissue plasminogen activator may be efficacious in restoring cerebral blood flow and thus limiting infarct size in acute thromboembolic stroke. |
| Databáze: | OpenAIRE |
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