Genome-wide analysis of Excretory/Secretory proteins in Trypanosoma brucei brucei: Insights into functional characteristics and identification of potential targets by immunoinformatics approach
| Autor: | Gowdham Manivel, Ruban Durairaj D, Arun Meyyazhagan, Shanmughavel Piramanayagam |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Proteome Trypanosoma brucei brucei Protozoan Proteins Genome wide analysis Computational biology Disease Biology Trypanosoma brucei 01 natural sciences Exocytosis Epitope Epitopes 03 medical and health sciences Databases Genetic parasitic diseases Genetics medicine African trypanosomiasis 030304 developmental biology 0303 health sciences Secretory Pathway Computational Biology Molecular Sequence Annotation Excretory secretory biology.organism_classification medicine.disease Identification (biology) 010606 plant biology & botany |
| Zdroj: | Genomics. 111:1124-1133 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/j.ygeno.2018.07.007 |
| Popis: | Trypanosoma brucei brucei (T.b.brucei) is an extra-cellular parasite that causes Animal African Trypanosomiasis (AAT) disease in animals. Till day, this disease is more difficult to treat and control due to lack of efficient vaccines and early diagnosis of the parasite infection. T.b.brucei Excretory/Secretory (ES) proteins were involved in pathogenesis and key for understanding the host-parasite interactions. Functions of T.b.brucei's ES proteins were poorly investigated and experimental identification is expensive and time-consuming. Bioinformatics approaches are cost-effective by facilitating the experimental analysis of potential drug targets for parasitic diseases. Here we applied several bioinformatics tools to predict and functionalize the annotation of 1104 ES proteins and immunoinformatics approaches carried out to predict and evaluate the epitopes in T.b.brucei. Secretory information, functional annotations and potential epitopes of each ES proteins were available at http://tbb.insilico.in . This study provides functional information of T.b.brucei for experimental studies to identify potential targets for diagnosis and therapeutics development. |
| Databáze: | OpenAIRE |
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