Placental Cytomegalovirus Infection
| Autor: | Kaleigh E. Lindholm, Mary C. O'Keefe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Placenta Diseases Congenital cytomegalovirus infection Asymptomatic Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Pregnancy Placenta Eosinophilic medicine Humans Pregnancy Complications Infectious Fetus business.industry Viral culture General Medicine medicine.disease Medical Laboratory Technology 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cytomegalovirus Infections Female Sensorineural hearing loss medicine.symptom business |
| Zdroj: | Archives of Pathology & Laboratory Medicine. 143:639-642 |
| ISSN: | 1543-2165 0003-9985 |
| DOI: | 10.5858/arpa.2017-0421-rs |
| Popis: | In the United States, cytomegalovirus is the most common congenital viral infection and the number 1 cause of nonhereditary sensorineural hearing loss. The vast majority of infants may be asymptomatic, especially if cytomegalovirus is contracted later in the pregnancy, and some symptoms may have a delayed onset. Therefore, it is important for the pathologist to identify the common histologic findings to help confirm the diagnosis so the child can be followed for late sequelae. Histologic examination of the placenta is important in live births and in cases of intrauterine fetal demise. Chronic lymphoplasmacytic villitis and fibrotic, avascular villi are the most common findings. When present, Cowdry A intranuclear and basophilic intracytoplasmic inclusions are characteristic. Immunohistochemistry for cytomegalovirus can highlight these inclusions as well as the associated eosinophilic debris. In addition, polymerase chain reaction or viral culture on placental or fetal samples can be performed for confirmation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|