Impact of genetic polymorphisms on opioid misuse: a scoping review
| Autor: | Junaid Ahmad Bhatti, Zia Choudhry, Sanjida Ahmed |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Morphine Clinical events business.industry Single-nucleotide polymorphism Opioid-Related Disorders Bioinformatics Polymorphism Single Nucleotide Fentanyl Analgesics Opioid 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cytochrome P-450 Enzyme System Opioid Pharmacogenetics Genetics Humans Molecular Medicine Medicine business 030217 neurology & neurosurgery Depression (differential diagnoses) medicine.drug |
| Zdroj: | Pharmacogenomics. 20:685-703 |
| ISSN: | 1744-8042 1462-2416 |
| Popis: | We conducted a scoping review on genetic polymorphisms associated with opioid intake-related adverse patient outcomes including behavioral, physiological and clinical outcomes. We searched for studies on Medline®, EMBASE®, CINAHL®, Psychinfo® and SNPedia® from January 2006 to January 2018. Our study identified 33 genes and 71 SNPs associated with opioid-intake related adverse patient outcomes: four studies showing associations of nine SNPs with clinical events (e.g., arrhythmia, length of stay and deaths); six studies showing associations of 13 SNPs with respiratory depression and 25 studies showing associations of 50 SNPs with opioid misuse behaviors. Available pharmacogenetic-tests covered polymorphisms associated with opioids metabolism and ignored polymorphisms associated with opioids transport, receptor-binding and signaling that were linked with respiratory depression and misuse behaviors. |
| Databáze: | OpenAIRE |
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