Cloning and sequence analysis of a human type A/B hnRNP protein
| Autor: | Farhat A. Khan, Anil K. Jaiswal, Wlodzimierz Szer |
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| Rok vydání: | 1991 |
| Předmět: |
Sequence analysis
hnRNP protein Molecular Sequence Data Biophysics RNA-binding protein Biology Heterogeneous ribonucleoprotein particle Biochemistry Heterogeneous-Nuclear Ribonucleoproteins 03 medical and health sciences Structural Biology RNA binding motif Domain structure Protein A/G Genetics Humans Amino Acid Sequence Binding site Cloning Molecular Molecular Biology Peptide sequence 030304 developmental biology Ribonucleoprotein 0303 health sciences Binding Sites Base Sequence 030302 biochemistry & molecular biology RNA Cell Biology DNA Molecular biology Ribonucleoproteins biology.protein HeLa Cells |
| Zdroj: | FEBS letters. 290(1-2) |
| ISSN: | 0014-5793 |
| Popis: | A cDNA encoding a 284 residue long type A/B hnRNP protein has been cloned. This protein, previously referred to as type C[(1987) J. Biol. Chem. 262, 17126–17137], is an RNA unwinding protein from HeLa 40S hnRNP with a high affinity for G- followed by U-rich sequences. The N-terminal part of the protein contains two consensus RNA binding domains present in a number of other RNA binding proteins. The C-terminal part is glycine-rich and contains a potential ATP/GTP binding loop. The distribution of charged amino acids is highly uneven and there are multiple potential phosphorylation sites. |
| Databáze: | OpenAIRE |
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