Schwannosis in Three Foals and a Calf
| Autor: | Kyle R. Taylor, Brian A. Summers, Andrew D. Miller, Ileana C. Miranda, William L. Castleman, Alexander de Lahunta |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Nervous system Pathology medicine.medical_specialty 040301 veterinary sciences Central nervous system Cattle Diseases Schwann cell Biology 0403 veterinary science White matter 03 medical and health sciences Myelin 0302 clinical medicine Central Nervous System Diseases medicine Animals Horses Parenchymal Tissue General Veterinary Myelin protein zero 04 agricultural and veterinary sciences Spinal cord medicine.anatomical_structure Peripheral nervous system Cattle Female Horse Diseases Schwann Cells 030217 neurology & neurosurgery |
| Zdroj: | Veterinary Pathology. 56:783-788 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/0300985819846872 |
| Popis: | Proliferation of ectopic Schwann cells within the central nervous system (CNS) parenchyma (schwannosis) in early life is most commonly associated with human neurofibromatosis type-2 and has been unrecognized in domestic animals. Three foals and a calf, 5 to 11 weeks old, with progressive neurological signs from birth were studied. Histologically, at multiple levels of the spinal cord, all animals had bilateral plaques of proliferative spindle cells, predominantly affecting the white matter adjacent to dorsal and ventral nerve roots and variably extending into the gray matter. Proliferating cells had strong intracytoplasmic immunoreactivity for the Schwann cell markers myelin protein zero and periaxin, highlighting the formation of peripheral nervous system (PNS) myelin within the spinal cord. In all cases, foci of disorganized neural tissue (glioneuronal hamartomas) were present, which in 2 cases formed a mass effect that resulted in syringohydromyelia. Neonatal presentation suggests a congenital maldevelopment of the nervous system, with spontaneous invasion of PNS-derived Schwann cells into the CNS. |
| Databáze: | OpenAIRE |
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