Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
| Autor: | E. P. Fedorova, A. A. Churin, N. V. Varlamova, L. A. Ermolaeva, L. A. Larionova, V. I. Chernov, O. V. Neupokoeva, T. I. Fomina, Evgeny Nesterov, T. Yu. Dubskaya, T. Yu. Lamzina, T. V. Vetoshkina, V. S. Skuridin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Drug Nervous system media_common.quotation_subject chemistry.chemical_element Pharmacology Kidney Technetium Nervous System General Biochemistry Genetics and Molecular Biology Body Temperature Mice 03 medical and health sciences Subcutaneous injection 0302 clinical medicine Aluminum Oxide Animals Medicine media_common business.industry Heart General Medicine Acute toxicity Rats 030104 developmental biology medicine.anatomical_structure Liver chemistry Toxicity Nanoparticles Female Rabbits Bone marrow Radiopharmaceuticals business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 161:371-373 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, (99m)Tc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink