A quantitative and ultrastructural study of substantia nigra and nucleus centralis superior in Alzheimer's disease
| Autor: | Angelo Schenone, Massimo Tabaton, Giovanni Luigi Mancardi, P. Romagnoli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1985 |
| Předmět: |
Nucleus centralis superior
Male Pathology medicine.medical_specialty pathology/ultrastructure Aged Alzheimer Disease pathology Cerebellar Nuclei pathology Female Humans Male Middle Aged Neurofibrils pathology/ultrastructure Neurons pathology Substantia Nigra pathology Substantia nigra Biology behavioral disciplines and activities Pathology and Forensic Medicine law.invention Cellular and Molecular Neuroscience law Alzheimer Disease mental disorders medicine Humans Aged Neurons Anatomy Middle Aged Substantia Nigra nervous system Cerebellar Nuclei Ultrastructure Paired helical filaments Neurofibrils Female Neurology (clinical) Electron microscope |
| Popis: | In four patients with presenile Alzheimer's disease (AD) and three age-matched controls a quantitative study of neurons and neurofibrillary tangles (NFT) in the substantia nigra (SN) and nucleus centralis superior (NCS) was performed. A significant neuronal loss, similar in both nuclei, was found in AD cases, while the incidence of NFT was remarkably higher in NCS. Moreover, no significant correlation between neuronal loss and number of NFT was detected. An electron-microscopic study revealed that the subcortical NFT in NCS are made up of paired helical filaments in spite of their globose round shape. |
| Databáze: | OpenAIRE |
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