Healing and Antisecretory Effects of Aqueous Extract of Eremomastax speciosa (Acanthaceae) on Unhealed Gastric Ulcers
| Autor: | Emakoua J, Paul V. Tan, George Enow-Orock, G.T. Siwe, André Perfusion Amang, G Mbah, Christophe Mezui, E Z Nkwengoua |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant Article Subject medicine.medical_treatment Indomethacin lcsh:Medicine Pharmacology medicine.disease_cause 030226 pharmacology & pharmacy Antioxidants General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Fibrosis Acanthaceae medicine Animals Humans Secretion Stomach Ulcer Acetic Acid chemistry.chemical_classification Wound Healing General Immunology and Microbiology Plant Extracts business.industry lcsh:R General Medicine medicine.disease Mucus digestive system diseases Rats Surgery Disease Models Animal Oxidative Stress 030104 developmental biology Enzyme chemistry Gastric Mucosa Gastric acid business Oxidative stress Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2017 (2017) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2017/1924320 |
| Popis: | Objective. This work investigated the healing and antisecretory effects of the aqueous extract ofEremomastax speciosaon “unhealed gastric ulcers” associated with gastric acid hypersecretion.Materials and Methods. “Unhealed gastric ulcers” were induced using indomethacin following the establishment of acetic-acid-induced chronic gastric ulcers. The extract (200 and 400 mg/kg, per os) was administered concomitantly with indomethacin (1 mg/kg, subcutaneously). The effects of the extract on both basal and histamine-stimulated gastric acid secretion were determined. Mucus secretion and oxidative stress parameters were measured, and histological assessment of ulcer healing was carried out.Results. The extract significantly promoted the healing process in rats subjected to “unhealed gastric ulcers” (82.4–88.5% healing rates). Treatment with the extract significantly reduced the basal (25.95–49.51% reduction rates) and histamine-stimulated (24.25–47.41%) acid secretions. The healing effect of the extract was associated with a significant (p<0.05) increase of mucus secretion and concentrations of antioxidant enzymes compared with the controls. The extract at the highest dose showed normalization of the mucosa, without glandular destruction and with the disappearance of fibrosis and lymphocyte infiltration.Conclusion. The abilities of the extract to increase mucus secretion, to reinforce antioxidant status, and to inhibit acid secretion would be some of the mechanisms by which this extract would accelerate the healing process in “unhealed gastric ulcers.” |
| Databáze: | OpenAIRE |
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