Reproducibility of MRI Dixon-Based Attenuation Correction in Combined PET/MR with Applications for Lean Body Mass Estimation
| Autor: | Petra Rust, Andreas Stadlbauer, Marius E. Mayerhoefer, Marcus Hacker, Ivo Rausch, Martin Lyngby Lassen, Thomas Beyer, Markus Hartenbach, Matthew D. DiFranco |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Multimodal Imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences symbols.namesake 0302 clinical medicine Fluorodeoxyglucose F18 Linear regression Image Processing Computer-Assisted Humans Medicine Whole Body Imaging Radiology Nuclear Medicine and imaging Plethysmography Whole Body Sex Characteristics Reproducibility business.industry Reproducibility of Results Soft tissue Total body Magnetic Resonance Imaging Mr imaging Pearson product-moment correlation coefficient Positron-Emission Tomography 030220 oncology & carcinogenesis Body Composition symbols Lean body mass Female Artifacts business Nuclear medicine Correction for attenuation Algorithms |
| Zdroj: | Journal of Nuclear Medicine. 57:1096-1101 |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.115.168294 |
| Popis: | The aim of this study was to assess the reproducibility of standard, Dixon-based attenuation correction (MR-AC) in PET/MR imaging. A further aim was to estimate a patient-specific lean body mass (LBM) from these MR-AC data. Methods: Ten subjects were positioned in a fully integrated PET/MR system, and 3 consecutive multibed acquisitions of the standard MR-AC image data were acquired. For each subject and MR-AC map, the following compartmental volumes were calculated: total body, soft tissue (ST), fat, lung, and intermediate tissue (IT). Intrasubject differences in the total body and subcompartmental volumes (ST, fat, lung, and IT) were assessed by means of coefficients of variation (CVs) calculated across the 3 consecutive measurements and, again, across these measurements but excluding those affected by major artifacts. All subjects underwent a body composition measurement using air displacement plethysmography (ADP) that was used to calculate a reference LBMADP. A second LBM estimate was derived from available MR-AC data using a formula incorporating the respective tissue volumes and densities as well as the subject-specific body weights. A third LBM estimate was obtained from a sex-specific formula (LBMFormula). Pearson correlation was calculated for LBMADP, LBMMR-AC, and LBMFormula. Further, linear regression analysis was performed on LBMMR-AC and LBMADP.Results: The mean CV for all 30 scans was 2.1 ± 1.9% (TB). When missing tissue artifacts were excluded, the CV was reduced to 0.3 ± 0.2%. The mean CVs for the subcompartments before and after exclusion of artifacts were 0.9 ± 1.1% and 0.7 ± 0.7% for the ST, 2.9 ± 4.1% and 1.3 ± 1.0% for fat, and 3.6 ± 3.9% and 1.3 ± 0.7% for the IT, respectively. Correlation was highest for LBMMR-AC and LBMADP (r = 0.99). Linear regression of data excluding artifacts resulted in a scaling factor of 1.06 for LBMMR-AC. Conclusion: LBMMR-AC is shown to correlate well with standard LBM measurements and thus offers routine LBM-based SUV quantification in PET/MR. However, MR-AC images must be controlled for systematic artifacts, including missing tissue and tissue swaps. Efforts to minimize these artifacts could help improve the reproducibility of MR-AC. |
| Databáze: | OpenAIRE |
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